The VHL gene product (pVHL) forms a multimeric complex with the elongin B and C, Cul2 and Rbx1 proteins (VCBCR complex), which is homologous to the SCF family of ubiquitin ligase complexes. The VCBCR complex binds HIF-1alpha and HIF-2alpha, transcription factors critically involved in ...
Together, Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complex--a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to ...
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英文别名: Recombinant Human Elongin B/Elongin C/VHL Complex, CF中文名: 中文别名: CBNumber: CB115325551 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 Recombinant Human Elongin B/Elongin C/VHL Complex, CF化学性质 ...
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, et al: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad...
-ElonginB-ElonginC-Cullin5-Rbx (Vif-CBF-??-EloB-EloC-Cul5-Rbx) E3 complex to induce their proteasomal degradation. EloB and EloC were initially reported as positive regulatory subunits of the Elongin (SIII) complex. Thereafter, EloB and EloC were found to be components of Cul-E3 ...
The VHL gene product (pVHL) forms a multimeric complex with the elongin B and C, Cul2 and Rbx1 proteins (VCBCR complex), which is homologous to the SCF family of ubiquitin ligase complexes. The VCBCR complex binds HIF-1α and HIF-2α, transcription factors critically involved in cellular...
Recombinant Human Elongin B/Elongin C/VHL/CUL2/RBX1, CF| 基本信息更多信息 中文名称: 中文同义词: 英文名称:Recombinant Human Elongin B/Elongin C/VHL/CUL2/RBX1, CF 英文同义词:Recombinant Human Elongin B/Elongin C/VHL/CUL2/RBX1, CF
elongin Belongin CRbx1HIF-1αVHLgenomic organizationchromosomal localizationmutationThe VHL gene product (pVHL) forms a multimeric complex with the elongin B and C, Cul2 and Rbx1 proteins (VCBCR complex), which is homologous to the SCF family of ubiquitin ligase complexes. The VCBCR complex ...
(2001). The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma. Oncogene 20: 5067-5074.Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, et al. (2001) The pVHL-associated SCF ubiquitin ligase ...