PURPOSE: To provide an elfamycin-resistant variant of elongation factor(EF) Tu which is used for reducing the elfamycin sensitivity of elfamycin-producing actinomycetes, esp. mocimycin-producing streptomyces.LUITEN RUDOLF GIJSBERTUS MARIEルドルフ ヘイスベルテュス マリー ライテンKERKMAN RICHARD...
This limiting factor for the production of the elfamycin concerned is removed by mutating the gene tuf, encoding the protein EF-Tu, into a gene tufR, encoding a protein EF-TuR, which protein is resistant to the elfamycin concerned. The gene tufR is expressed in host cells which than ...