(n=3) mice. *P<0.05, unpairedt-test. (e) SOM-positive cells were counted in the hippocampal CA1, CA3 and DG regions. 10W, WT,n=5; 10W KO,n=6; 4M WT,n=5; 4M KO,n=4 mice.#P=0.08, WT versus KO, unpairedt-test. See alsoSupplementary Fig. S7;Supplementary Table 1and...
However, to our knowledge, there have been no reports of mGluR7 regulators other than glutamate and its synthetic agonists, such as L-AP4 and AMN082, which can bind the N-terminal ectodomain. Elfn1 is thus the first identified endogenous transregulator of mGluR7. The seizure-prone phenotype ...