Based on these findings, it is suggested that the increased level of total NF proteins in CSF could be used as a marker for brain aging and neurodegenerative disorders in general, and the levels of pNF-H/M as a marker to discriminate AD from normal brain aging and as well as neurological...
The CSF/serum albumin ratios, CSF/serum IgG ratios and the CSF-total protein concentrations were higher in men than in women among the patients. We suggest that the significant difference in ratio parameters between patients and controls indicates a leak of plasma albumin, most likely IgG, into...
The CSF CXCL13 concentrations seemed to associate with CSF white blood cell counting, total protein concentration in NMO subgroup, thought did not quite reach statistical significance (WBC, p=0.473; TP, p=0.276). The concentration of CSF CXCL13 was elevated in NMO patients, and correlated with...
The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer’s disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β form...
Protein Gels (Bio-Rad, Cat no 4561094) for gel electrophoresis and transferred using the Trans-Blot Turbo Mini 0.2 μm PVDF Transfer Packs (BioRad, Cat no. 1704156) and semi-dry transfer system. PVDF membranes were then blocked for 1 h in a solution of equal parts TBS and Intercept (...
Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydroceph... Background Phase-contrast magnetic resonance imaging (PC-MRI) enables quantification of cerebrospinal fluid (CSF) flow and total cerebral blood (...
People's Republic of China Correspondence: Jun Liu Email jly0520@hotmail.com Objectives: Cerebrospinal fluid (CSF) visinin-like protein 1 (VILIP-1) has been suggested as a biomarker for neuron injury, which has been shown to have a important diagnostic value in symptomatic Alzheimer's disease...
The total number of positive immunoreactive cells (p-ERK, p-P38, Iba1, c-FOS, CXCL12, CXCR4) and the relative fluorescence density of other signaling in each section were calculated by ImageJ software (National Institutes of Health, Bethesda, MD) to show the protein expression. The ...
It has been reported that S-100β protein, a calcium-binding protein abundant in glial and Schwann cells, is increased in blood and cerebrospi- nal fluid (CSF) after ischemic stroke and its plasma concen- tration correlates positively with the size of infarct volume in humans (26, 27). ...
An anomaly in the plasma proteins of patients with multiple sclerosis detectable on SDS-PAGE has been reported. The molecular weight of the anomaly was the same as the phospholipid transfer protein. A metabolic protein was involved in lipid homeostasis and remodeling of the high density lipoproteins...