Patients with T2DM exhibited significantly elevated mRNA levels of senescence (GLB1, p16, p21, and p53) and inflammatory (IL6 and TNF-伪) markers, shortened telomeres as well as elevated levels of estrogen-related receptor gamma (ERR纬), a recently identified receptor for BPA. BPA levels were...
With a series of estrogen analogues, there was a direct correlation between the rise in renal ODC in vivo and the binding to renal estradiol receptor sites in vitro. The hamster kidney levels of the polyamines putrescine, spermidine and spermine all declined during the 180-day experimental period...
I am perplexed. The symptoms I am experiencing all point to low progesterone/estrogen dominance. Some of the symptoms—such as the night sweats, intense sugar cravings, and itchy skin worsens during the second half of my cycle. Could it be that even with these “in range” levels it’s ...
Background: Although estrogen has been regarded as a risk factor for endometrial carcinoma, its concentration-dependent carcinogenetic effects remain unclear, because most endometrial carcinomas occur in post-menopausal women, whose serum estrogen levels are relatively low. Because impaired mismatch repair...
Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Triple-negative breast cancer (TNBC) is characterized by the lack of expression of estrogen receptor-伪 (ER-伪), progesterone receptor (PR), and human epid... NH Ha,VS Nair...
Obesity is associated with breast white adipose tissue (WAT) inflammation, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that have been linked to the pathogenesis of breast cancer. Here, we determined whether metabolic obesity, including changes in breast biology ...
Estrogen deficiency is an important pathogenetic factor in female osteoporosis, and androgens are known to have anabolic effects on bone. In this study we have compared 12 men with idiopathic osteoporosis, age 27–55 years, with 12 age-matched men, with respect to serum levels of sex steroids,...
Bovine cytosol estrogen (ERC) and progesterone receptor (PRC) concentrations were measured simultaneously in various regions of the uterus and in ovarian s... M Vesanen - 《Acta Veterinaria Scandinavica》 被引量: 19发表: 1993年 Influence of Epidermal Growth Factor and Steroids on the Proliferation...
Experiments with a mouse model revealed that high levels of estrogen rapidly close the receptivity window for embryo implantation by altering endometrial gene expression, which causes the uterus to become unreceptive for implantation15,16. As a consequence of this shortened receptivity window caused by ...
Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism include diseases of the adrenal cortex, testis or medications affecting the hypothalamus-pituitary-gonadal axis. The aim of our study was to elucidate the effects of estradiol treatment on testicular cellular morpho...