Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Milosavljevic D, Brücke T, Bayer P, Hübl W: Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis - PresslauerPresslauer S, Milosavljevic D, Brucke T, Bayer P, Hubl W (2008) Elevated levels of kappa free light chains in CSF support the diagnosis...
Isotype variants were based on human IgG1 (G1m(f) isotype) and IgG3 (P01860), all variants were co-expressed with kappa light chain. Gene constructs for heavy and light chains were designed to include a cleavable signal sequence for secretion and were flanked by restriction sites to allow...
However, in severe patients, levels of free sphingoid bases were highly increased. These differences in S1P and Spa1P levels between mild and severe psoriasis patients indicate that differences in skin inflammation may be reflected also in other biological compartments. Both sphinganine and sphingosine ...
Light chains are classified as either kappa or lambda (κ, λ). Each heavy chain class can be bound with either a kappa or lambda light chain. In general, the light and heavy chains are covalently bonded to each other, and the “tail” portions of the two heavy chains are bonded to ...
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014;276:175-9.Hassan-Smith, G., Durant, L., Tsentemeidou, A., Assi, L.K., Faint, J.M., Kalra, S., et al., 2014. High sensitivity and specificity...
Kappa and lambda free light chains of immunoglobulins and beta2-microglobulin were not associated with changes in systemic disease activity. An elevated serum BAFF level was significantly more frequently associated with the occurrence of a new moderate/high domain at 1 and 3 years (20.0% vs 7.7%...
Free light chainsHigh amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, SLE, SjS, Scl, APS, UCTD, MCTD) ...
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014;276:175-9.Hassan-Smith, G., Durant, L., Tsentemeidou, A., Assi, L.K., Faint, J.M., Kalra, S., et al., 2014. High sensitivity and specificity...