Testosterone and 17尾-estradiol concentrations were determined during chronic high intoxication, over a withdrawal time course, and following a period of abstinence using a genetic model of withdrawal vulnerability, the Withdrawal Seizure-Resistant (WSR) and -Prone (WSP) selected lines. In males, ...
This treatment resulted in maternal neuroendocrine-driven testosterone excess and diminished placental metabolism of testosterone to estradiol, resulting in a masculinization of the exposed female fetus and a PCOS-like reproductive and neuroendocrine phenotype in adulthood. We found that the affected females...
In the present study I investigate these four areas using Cope’s gray treefrogs (Hyla chrysoscelis), a prolonged breeding species, at natural breeding aggregations and sampled for corticosterone, testosterone, and 17β-estradiol (hereafter CORT, T, and E2, respectively)....
Effects of an estrogen antagonist on enzyme activities and [3H]estradiol nuclear binding in uterus, pituitary and brain. The estrogenic and anti-estrogenic properties of CI-628 on these specific biochemical markers of estrogen action was not identical in the different target tissues. The CI-628 dep...
Precocious puberty wks post-conceptional was age o-bsPeCrAv)edfemianlea.prAtete4r1m (27 wks PCA, estradiol (E2) levels were elevated (282 pg/ml). By 13 months PCA, E2 decreased spontaneously (18 pg/ml) and pubertal changes regressed. However, pelvic ultrasonography revealed the development...
EstradiolDihydrotestosteroneInhibinsCase-Control StudiesAdiponectinAdultInfant, NewbornInfant, Small for Gestational AgeMaleCONTEXT: Prenatal growth restriction may affect future fertility in both females and males. Studies have shown that growth-retarded male rats have different sexual behavior and disturbed ...
This treatment resulted in maternal neuroendocrine-driven testosterone excess and diminished placental metabolism of testosterone to estradiol, resulting in a masculinization of the exposed female fetus and a PCOS-like reproductive and neuroendocrine phenotype in adulthood. We found that the affected females...
Our previous studies have shown that maternal high estradiol (E2) environment increased the risk of thyroid dysfunction in offspring. However, the mechanism involved remains unexplored. To evaluate the thyroid function of offspring after high E2exposure and to explore the underlying mechanism, we ...
However, there is no evidence for direct regulation of Efnb2 in Ocy454 cells by either estradiol or testosterone. We suggest that changes in bone matrix composition may play a more significant role in determining bone strength in female bones because they have higher mineral content and more ...
There were no significant differences in the percentage of entries into the open arms or in the number of entries into the closed arms among the phases of the estrous cycle or between males and normal or ovariectomized females. Serum estradiol levels were higher (P<.05) during proestrus ...