Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis. J. Cachexia Sarcopenia Muscle 2017, 8, 915-925. [CrossRef] [PubMed]Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, Ishii N, et al. Elevated serum myostatin level is associated with ...
Glutamate, a metabolite involved in the production of free ammonia (a hepatotoxic molecule), showed a marked elevation in the hTBA+Alc group (Figure 7C). Furthermore, hypoxanthine, a purine derivative that consumes NAD+,36 was notably higher in the hTBA+Alc group (Figure 7D). Hepatic 3-...
We have previously shown that ammonia induces an elevation of the neuronal tricarboxylic acid cycle activity. Thus, the aims of the present study were to determine if increased levels of ammonia increase GABA synthesis via the indirect pathway in a rat model of HE induced by bile-duct ligation ...
(Hepa-Merz篓) infusion on serum ammonia level in patients with liver cirrhosis accompanied by hyperammonaemia.Fourty patients received ornithine-aspartate (20 g in 250 ml 0,9% NaCl infusion solution administered intravenously during four hours) and 40 patients received placebo (250 ml 5% fructose...
cirrhosisGABA synthesisglutaminehepatic encephalopathyTCA cycleHepatic encephalopathy (HE) is a neuropsychiatric complication to liver disease. It is known that ammonia plays a role in the pathogenesis of HE and disturbances in the GABAergic system have been related to HE. Synthesis of GABA occurs by...