A comparative metabolic analysis between cell lines or primary cells allows to establish a specific metabolic profile and to detect possible alterations of the mitochondrial function of a tumor cell. Moreover, the direct measurements of electron flux triggered by metabolic pathway activation could high...
Traditional Electron Transport Chain Recap Theelectron transportchain is a mitochondrial pathway in which electrons move across a redox span of 1.1V from NAD+/NADH to O2/H2O. Three complexes are involved in this chain, namely, complex I, complex III, and complex IV. Some compounds likesuccinate...
cancer cells with mutations in ND2 exhibit a glycolytic metabolic profile; interestingly, these cancer cells also exhibited increased metastatic potential.30In addition, the downregulation of NDUF
Electron transportchain is a mitochondrial pathway in which electrons move across a redox span of 1.1V from NAD+/NADH to O2/H2O. Three complexes are involved in this chain, namely complex I, complex III and complex IV. Some compounds such as succinate which have more positive redox potential...
pathway used to oxidize the organic energy source e.g., pyruvate does not involve the use of an electron transport chain nor the generation of a proton motive force ATP synthesized only by substrate-level phosphorylation 5 Energy Sources many different energy sources are funneled into common ...
(the very end of the electron-transport chain), we used a different terminal electron acceptor (O2) than in the AHDSredoxidation screen. The use of O2also ensures that the genes identified are part of the overlapping electron-uptake pathway, rather than previously unidentified components of ...
(2000). Measuring the quantity and activity of mitochondrial electron transport chain complexes in tissues of ... HZ Xu - 《Analytical Biochemistry》 被引量: 147发表: 2000年 Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans - ScienceDirect Caenorhabditis elegans ...
(4) Conclusions: During mechanical effort, the reduced iron availability enhances anaerobic glycolysis and extracellular lactate production, whilst decreasing mitochondrial aerobic pathway in HCM. Iron enrichment during mechanical effort may be protective in the context of intracellular protein machinery of ...
the influence of this metabolic pathway was minimized in two different ways. First, cells were incubated in DMEM without glucose and pyruvate but containing 4 mM glutamine, a substrate that is metabolized to produce α-ketoglutarate, an intermediate of the citric acid cycle. For comparison, expe...
We hypothesize that this increase serves to maintain the redox balance of the photosyn- thetic electron transport chain. In the absence of alkanes, increased CEF represents a less energy-efficient pathway that leads to slower growth at suboptimal temperatures. The low temperature of 20 C used ...