(2012) The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat. Struct. Mol. Biol., 19, 498-505.Melero R, Buchwald G, Castano R, et al: The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat Struct ...
acomplex (CBC) named ARS2, a component of the exonjunction complex (EJC) named Acinus, and the U5 snRNP component, Brr2. 复杂 (CBC) 命名了ARS2、exonjunction复杂EJC说出的Acinus的 () 组分和U5 snRNP组分, Brr2。 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语...
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The exon junction complex (EJC) is believed to mediate the link between splicing and NMD in these systems. Here, we report that in Schizosaccharomyces pombe splicing also enhances NMD, but against the EJC model prediction, an intron stimulated NMD regardless of whether it is positioned upstream ...
Mago and Y14 are core components of the exon junction complex (EJC), an assembly central to nonsense-mediated mRNA decay in humans and mRNA localization in flies. The Mago-Y14 heterodimer shuttles between the nucleus, where it is loaded onto specific mRNAs, and the cytoplasm, where it functi...
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It is possible that the redundancy which has been reported between export components binding nuclear pore complex may compen- sate depletion of Nxf1 (refs 41,42). Alternatively, in our SKD mutant, a residual Nxf1 function could be sufficient to allow the export of enough flam precursors that...
27. Nxt1 enhances Nxf1-dependent RNA export by stimulating Nxf1 interactions with the nuclear pore complex28,29. Binding of the Nxf1–Nxt1 heterodimer to mRNAs is thought to be mediated by adaptor proteins. Consistently, EJC has been shown to facilitate the recruitment of Nxf1 to spliced ...
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