eif2ak3,也被称为PERK(PKR-like endoplasmic reticulum kinase),是一种位于内质网的i型膜蛋白。当内质网应激发生时,eif2ak3被激活,通过磷酸化真核生物翻译起始因子2(eIF2)的α亚单位,导致eIF2失活,从而迅速减少翻译起始并抑制全球蛋白质合成。此外,eif2ak3还可以磷酸化NRF2,从而促进NRF2从NRF2-Keapl复合体中解...
基因别名:EIF2AK3; PEK; PERK; WRS UniProt ID:(Human) Q9NZJ5 Entrez Gene ID:(Human) 9451 Cookie设置 我们及我们的关联方等通过运用Cookie等技术来为您提供您感兴趣的网站定制内容、识别访问者、保障安全登录和收集数据。点击“全部接受”以接受所有 cookie 并直接跳转至网站,或点击“管理设置”以查看 cookie...
Eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3; PERK); eukaryotic translation initiation factor 2A (EIF2A)Mouse studies suggest inhibiting PERK and EIF2A signaling could help treat radiotherapy-resistant cancers.Science-Business eXchange...
The pathological characteristics of osteonecrosis of the femoral head. (A) H&E staining. (B) Masson’s staining. Three cases represented samples selected randomly from three individuals. Scale bar = 50 μm. The expression of BMP2 (
Eukaryotic translation initiation factor 2 alpha kinases (eIF-2α kinases or eIF2AKs) are a family of four distinct serine-threonine kinases, including HRI (Heme-Regulated Inhibitor; eIF2AK1), PKR (RNA-dependent Protein Kinase; eIF2AK2), PERK (PKR-like ER Kinase; eIF2AK3) and GCN2 (...
基因别名:EIF2AK3; PEK; PERK; WRS UniProt ID:(Human) Q9NZJ5 Entrez Gene ID:(Human) 9451 Cookie设置 我们及我们的关联方等通过运用Cookie等技术来为您提供您感兴趣的网站定制内容、识别访问者、保障安全登录和收集数据。点击“全部接受”以接受所有 cookie 并直接跳转至网站,或点击“管理设置”以查看 cookie...
We report a patient with WRS born to a consanguineous marriage due to a novel biallelic frameshift mutation in the EIF2AK3 gene.doi:10.1186/s12887-019-1432-8Fatani, Tarah H.BioMed CentralBMC Pediatrics
Eukaryotic translation factor 2|[alpha]| kinase 3 (EIF2AK3; PERK); EIF2AK4 (GCN2)Patient sample and mouse studies suggest inhibition of PERK or GCN2 could help treat AD. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business...
This paper aims at designing a computer-assisted, structure based drug of an effective inhibitor of human EIF2AK3 (PERK) gene, a target protein for Progressive Supranuclear Palsy (PSP), a degenerative neurological disorder of uncertain aetiology, caused mainly by mutation of tau gene. Discovery ...
Liu J, Hoppman N, O’Connell JR, Wang H, Streeten EA, McLenithan JC, Mitchell BD, Shuldiner AR (2012) A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density. J Bone Miner Res 27:331–341. : 10.1002/jbmr.549 Central...