The role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress. Curr Mol Med 2016;16(6):533-544.Rozpedek W, Pytel D, Mucha B et al. The role of the PERK/eIF2alpha/ATF4/CHOP signaling pathway in tumor progressi...
Morin was found to downregulate PERK-eIF2 alpha-ATF4 pathway by interacting with PERK protein as confirmed through pull-down assay. Additionally, Morin maintained the reducing environment in ER and enhanced PDI activity compared to diabetic rats. Morin prevented cell death by suppressing the ...
eIF2 alpha-ATF4 pathwayThe heavy metal cadmium (Cd) is well known to be neurotoxic. Studies have shown that apoptosis plays an essential role in Cd-induced brain injury; however, the mechanisms underlying this injury accompanied by apoptosis have yet to be elucidated. The endoplasmic reticulum (...
Collectively, our findings show that 20(S)‐PPD inhibits HUVEC growth by inducing apoptosis and that ATF4 expression activated by the PERK‐eIF2α signaling pathway is essential for this process. These findings suggest that high concentrations of 20(S)‐PPD could be used to treat angiogenesis‐...
GCN2 was also found to decrease levels of IL-1 beta and TNF-alpha, and inhibit neutrophil infiltration activation. In addititon, GCN2 also alleviated long-term neurological impairment after ICH. However, inhibition of eIF2 alpha or ATF4 abolished the protective effects of GCN2, indicating eIF2...
Then in vitro and in vivo experiments were performed to further elucidate the molecular mechanism of THD in CRC.Results THD was found to induce endoplasmic reticulum (ER) stress in CRC cells by activating the eIF2a/ATF4/CHOP axis and facilitating the accumulation of secretory autophagosomes, ...
Public health Boric Acid Causes ER Stress and Activates the eIF2alpha/ATF4 and ATF6 Branches of the Unfolded Protein Response in Prostate Cancer Cells and Using Toxicology in the Public Interest UNIVERSITY OF CALIFORNIALOS ANGELES Curtis D. Eckhert KobylewskiSarah Ellen...
Furthermore, siRNA-mediated knockdown of PERK or ATF4 inhibited the induction of CHOP expression and 20(s)-PPD-induced apoptosis. Collectively, our findings show that 20(S)-PPD inhibits HUVEC growth by inducing apoptosis and that ATF4 expression activated by the PERK-eIF2伪 signaling pathway is...
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2 alpha-ATF4 axissterolendoplasmic reticulum stresscell deatheukaryotic initiation factor 2stress responseactivating transcription factor-4oxysterolY Insulin-induced genes (INSIGs) encode endoplasmic reticulum-...
p-eIF2 alphaThis study aimed to investigate whether cadmium induces ovarian granulosa cell damage by activating protein kinase R-like endoplasmic reticulum kinase (PERK)-eIF2 alpha-ATF4 through endoplasmic reticulum (ER) stress and to elucidate the underlying regulation mechanism. Two models of ...