Release of arachidonic acid and eicosanoids in rat peritoneal macrophages: role of cytosolic calcium ionsGLOMERULAR CAPILLARY PRESSUREGLOMERULAR FILTRATION RATEPOSTGLOMERULAR RESISTANCEPREGLOMERULAR RESISTANCERENAL BLOOD FLOWRENAL VASCULAR RESISTANCESODIUM EXCRETION RATE...
Arachidonic acid (ARA), an n-6 essential fatty acid, plays an important role in human and animal growth and development. The ARA presents in the membrane phospholipids can be released by phospholipase A2. These free arachidonic acid molecules are then used to produce eicosanoids through three ...
The eicosanoids, so called because of their derivation from a 20-carbon unsaturated fatty acid, arachidonic acid (eicosatetraenoic acid), are obtained from membrane phospholipids and synthesized de novo at the time of cellular stimulation. Arachidonic acid is cleaved from membrane-bound phosphatidylcholine...
a, time course for PAF-mediated generation of arachidonic acid. Basal, basal control; PAF, PAF stimulation in control cells; PAF + MAF, PAF stimulation in cells pretreated with the dual cPLA2 and iPLA2 inhibitor. Results are the mean ± S.D. for triplicate measurements and from three ...
Any of a group of substances that are derived from arachidonic acid, including leukotrienes, prostaglandins, and thromboxanes. [eicosan(e),chemical name(Greekeikosi,twenty, from its twenty carbon atoms; seewīkm̥tī-inIndo-European roots+-ane) +-oid.] ...
of eicosanoids comes from eicosapentaenoic acid derived from α-linolenic acid. The main source of arachidonic acid is cellular stores release. Inside the cell, arachidonic acid localized primarily at the C–2 positions of membrane phospholipids and the release is triggered by the activation of PLA2...
Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that regulate a wide variety of physiological responses and pathological processes. They are produced by various cell types through distinct enzymatic pathways and act on target cells via specific G-protein-coupled...
Eicosanoids are signaling molecules generated through enzymic oxidation of arachidonic acid (ARA, 20:4n-6) by cyclooxygenases (COX-1 and 2) (O’Banion, 1999; Vane et al., 1998; Phillis et al., 2006), lipoxygenases (LOX) (Kuhn and O’Donnell, 2006; Kim et al., 2008), and epoxygena...
Lipids play a key role in many cellular systems as they are a major components of cell membranes and key cellular energy sources. Arachidonic acid (AA) is produced when the COVID-19 virus induces the plasma membrane to secrete phospholipase 2 (cPLA2). AA is then converted to pro-inflammato...
Eicosanoids are a family of bioactive lipids formed from arachidonic acid and include prostaglandins, leukotrienes and related compounds. Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress prostaglandins and are widely used for anti-pyretic, analgesic and anti-inflammatory effects. NSAIDs selective for...