A value of P < 0 .05 was considered statistically significant. References 1. Manning, G., Whyte, D. B., M artinez, R., Hunter, T. & Sudarsanam, S. The Protein Kinase Complement of the Human Genome. Science. 298, 1912–1934 (2002). 2. Zuccotto, F., Ardini, E., ...
The cutoff value of eGFR was 60 ml/min/1.73 m2. The patients were subsequently divided into 2 groups according to their renal function, as assessed by eGFR: 1st group with eGFR 60-90 ml/min/1.73 m2 and 2nd with eGFR90 ml/min/1.73 m2. The primary end-point was all-cause mortality ...
Overall, the concordance rate of intratumoral EGFR expression (0, 1+ vs 2+, 3+) was 90% (94/105) with a mean kappa value of 0.836 (P<0.001) (Table 4). The concordance rate of intratumoral EGFR copy number alteration (low gene copy number vs high gene copy number) was 86% (89/...
Therefore, monitoring immune response after MAb treatment could provide insight into the value of induction of specific and efficient T cells with clinical benefit. Nimotuzumab-activated NK cells induce DC maturation and TA-specific CD8+ T cells. In addition, nimotuzumab is able to restore HLA-I ...
The results provide a preclinical rationale for the use of HSP90 inhibitors to overcome EGFR amplification‐mediated resistance. Abstract Third‐generation EGFR‐TKIs overcome EGFR T790M‐meditated resistance. However, amplified EGFR confers resistance to third‐generation EGFR‐TKIs. Inhibiting HSP90, ...
The value of clinical and CT features in predicting EGFR mutation of lung adenocarcinoma HUO Ji-wen,LI Qi,LUO Tian-you,et al.Department of Radiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing400016,China 【Abstract】Objective：To explore the value of clinical and CT ...
The overall data of the FLAURA trial in China revealed a consistent trend with global data, which has great reference value for the clinical application and scientific research of osimertinib in China. Almonertinib (also named HS‑10296). The APPLLO (NCT02981108) trial was a phase 2, open...
a 50-fold increase in the growth inhibitory 50% (GI50) value of osimertinib. Structural modeling showed that the side chain of the mutated G796D residue collides with the surface of osimertinib, resulting in steric hindrance and energy repulsion and ultimately the loss of binding affinity [27]...
Compound 4c was the most potent compound in the series showing 1 nM of IC50 value in ELISA H1975 assay. However, it was the least stable in the liver microsomal stability study, resulting in the least inhibitory effect in the animal models among the compounds tested. 2a showed good rat ...
limiting its efficacy.Molecular targeted therapy is a driver gene-guided therapy,which has opened the era of "individualized"and "precise"treatment for non-squamous non-small cell lung cancer.This article reviews the clinical value and drug resistance mechanism of EGFR-TKI in the treatment of ...