Precision oncology comprises the set of strategies that aim to design the best cancer treatment based on tumor biology. A recognized subset of patients with non-small cell lung cancer (NSCLC) harbor actionable genomic aberrations that can benefit from targeted therapy. In lung cancer, epidermal ...
[10]Chen H, Liu M, Dai Z, et al. Concomitant genetic alterations are associated with response to EGFR targeted therapy in patients with lung adenocarcinoma. Transl Lung Cancer Res. 2020 Aug;9(4):1225-1234. DOI: 10.21037/tlcr-20-679 [11] Roeper J, Falk M, Chalaris-Rißmann A, ...
[10]Chen H, Liu M, Dai Z, et al. Concomitant genetic alterations are associated with response to EGFR targeted therapy in patients with lung adenocarcinoma. Transl Lung Cancer Res. 2020 Aug;9(4):1225-1234. DOI: 10.21037/tlcr-20-679 [11] Roeper J, Falk M, Chalaris-Rißmann A, et...
近日,上海交通大学医学院药理学与化学生物学系朱亮课题组在《Science Translational Medicine》期刊在线发表了题为“Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR- targeted therapy in lung cancer”的研究成果,该研究揭示了肺癌EGFR-TKI耐药新机制并提示克服耐药新治疗...
2021年10月7日,上海交通大学医学院药理学与化学生物学系朱亮课题组在Science Translational Medicine期刊在线发表题为Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR- targeted therapy in lung cancer...
Targeted therapy for EGFR wild-type lung adenocarcinoma: A case report 作者:刘斌,黄彭,刘双柏,梁彦超,谢波 中国是肺癌大国,其发病率和病死率均位居所有恶性肿瘤的首位。而晚期肺癌传统治疗手段 主要为放化疗。IPASS研究结果显示:EGFR基因突变的患者接受吉非替尼治疗的...
10月7日,上海交通大学医学院药理学与化学生物学系朱亮课题组在ScienceTranslationalMedicine期刊在线发表题为“TargetingAKR1B1inhibitsglutathionedenovosynthesistoovercomeacquiredresistancetoEGFR-targetedtherapyinlungcancer”的研究成果,揭示肺癌EGFR-TKI耐药新机制并提示克服耐药新治疗手段。
2021年2月,靶向治疗领域著名期刊Signal Transduction and Targeted Therapy(IF=13.5)在线发表了题为“The impact of postoperative EGFR-TKIs treatment on residual GGO lesions after resection for lung cancer”的研究[1]。广州医科大学附属第一医院、广州呼吸健康研究院、国家呼吸医学中心何建行教授、梁文华教...
[6] Wang Q, Yang S, Wang K and Sun SY: MET inhibitors for targeted therapy of EGFR TKI‑resistant lung cancer. J Hematol Oncol 12: 63, 2019. [7] Drilon A, Cappuzzo F, Ou SI and Camidge DR: Targeting MET in lung cancer: Will expectations finally Be MET? J Thorac Oncol 12: ...
2021年2月,靶向治疗领域著名期刊Signal Transduction and Targeted Therapy(IF=13.5)在线发表了题为“The impact of postoperative EGFR-TKIs treatment on residual GGO lesions after resection for lung cancer”的研究[1]。广州医科大学附属第一医院、广州呼吸健康研究院、国家呼吸医学中心何建行教授、梁文华教授为共同...