characteristics, including age, sex, Eastern Cooperative Oncology Group (ECOG) status, smoking status, ethnicity, and brain metastasis, showed that osimertinib plus chemotherapy and lazertinib plus amivantamab ranked first and second for almost all clinicopathological characteristics (Table 2). The...
In H1975 (L858R/T790M) and PC-9 VanR (Del19/T790M) resistant cell lines, activity of osimertinib was reported with mean IC50 potency of <15 nmol/l (Table 1) [11]. Osimertinib is more selective to the mutated receptor as evidenced by a high IC50 (range from 480 to 1865 nmol/l...
age (≥18 years), and patient sex; patient race (African versus non-African ancestry) is no longer considered.4Alternative calculations have been proposed for patients under age 18 years, but they are not offered by Quest at present. Quest test codes that include eGFR are list...
low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen, serum uric acid (SUA), creatinine, and estimated glomerular filtration rate were compared between the hyperuricemia group and the normal uric acid group at baseline (Table 1)...
Table 1. Patient characteristics (N = 1431). *including R0(un) PS, performance status; MLND, mediastinal lymph node dissection; EGFR,epidermal growth factor receptor 3.3 Prognosis of patients with lung adenocarcinoma harboring common EGFR m...
S4e). In order to determine the MOB1 phosphorylation sites, all 8 tyrosine sites of MOB1 were mutated into an unphosphorylatable amino acid, phenylalanine (MOB1 8YF). As expected, while MOB1 WT was phosphorylated by EGFR activation, MOB1 8YF was not (Fig. 4a). We then performed an...
Oxford classification scores were detailed in Table 1. Prior or at the time of biopsy, 65 patients (87.8%) had used angiotensin converting enzyme inhibitors (ACEi) or angiotensin-receptor blockers, while five patients (6.7%) had received immunosuppressive agents. During follow-up, all patients ...
The study was approved by the institutional review board of Seoul National University Bundang Hospital (IRB No. B-1005/100-303), which waived the requirement for informed consent. Table 1. Baseline characteristics of 151 patients with triple-negative breast cancer CharacteristicsNumber (%) Age, ...
www.bjcancer.com | DOI:10.1038/bjc.2013.577 2163 BRITISH JOURNAL OF CANCER Combination immunotherapy with EGFR inhibitors Table 2. Assessment of T-cell responses to the EGFR875–889 peptide in HNSCC patients and healthy donors EGFR 875 anti-HLA-DR mAb Age Pathological No. Sex (y) stage ...
Not everyone produces the same amount of creatinine, which is why eGFR calculators can include factors such as age, sex, and race along with your creatinine levels to estimate the GFR. While most commonly used, creatinine is not the only substance that can be used to estimate GFR. For examp...