MEANS AND METHODS FOR DETERMINING EFFICACY OF ANTI-EGFR INHIBITORS IN COLORECTAL CANCER (CRC) THERAPYThe present invention relates to a method for determining the susceptibility/responsiveness of (a) cancer cell(s), preferably (a) colorectal cancer cell(s), to the treatment with an epidermal ...
HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 functions mainly through dimerization with other family members, such as EGFR.
Combination therapy targeting different pathways of cancers proved to be efficacious by means of synergistic and/or additive mechanisms. However, the concurrent use of two or more drugs still is a challenge in clinical therapy due to various dose-limiting toxicities and drug-drug interactions caused ...
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Data are means ± SD of three independent experiments. ns, not significant, *p < 0.05, **p < 0.01. Ctrl, control; Gef, Gefitinib; Osi, Osimertinib. Full size image NSUN2 overexpression promotes gefitinib resistance in vitro and in vivo To determine whether NSUN2-mediated ...
Pretreatment with kahweol by gavage for 5 days somewhat alleviates lung pathological injury, infection, and oxidative anxiety, associated with shifting the powerful means of mitochondria from fission to fusion, boosting mitophagy, and activating AMPK. To explore the underlying molecular mechanisms, ...
In other words, a tumour can simultaneously harbour an activating EGFR mutation as well as mutations downstream of the pathway in the KRAS gene, which means that upstream inhibition of EGFR with TKIs will have no therapeutic effect in these cases. This finding also suggests that the EGFR ...
Total RNA was harvested for the analysis of mRNA by real-time RT-PCR. F CD133 + cells detected by flow cytometry according to PC-9 cells with different status of BTK expression and Gefitinib resistance. The results are shown as the means ± SD of three independent experiments, ...
The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.</d
Suitable variants can be obtained by means of methods of sequence alteration, or mutation, and screening. In a preferred embodiment, a specific binding member comprising one or more variant sequences retains one or more of the functional characteristics of the parent specific binding member, such ...