Extracellular Vesicle–Mediated Transfer of a Novel Long Noncoding RNA TUC339 A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. We have id...
6A). However, we found that TGFα increased the level of active (nonphosphorylated) β-catenin and that this increase was abolished by inhibitors for EGFR (gefitinib), MEK/ERK (U0126), and p38 kinase (SB203580) pathways (Fig. 6A). Download: Download high-res image (205KB) Download: ...
The discovery of mutated oncogenes has changed the standard approach in advanced non-small cell lung cancer (NSCLC) patients and opened up a new era for the development of personalized treatment for those patients with sensitizing mutation of the Epidermal Growth Factor Receptor (EGFR). Nevertheless...
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. Cancer Res. 2004;64(12):4190–6. Epub 2004/06/19. CAS PubMed Google Scholar Chung E, Graves-Deal R, Franklin JL, Coffey RJ. Differential effects of amphiregulin and TGF-alpha on the morphology of ...
A higher cell proliferation inhibition was achieved with MDA-MB-231 overexpressing MT4- MMP than non-expressing cells: 6.5-fold for epirubicin at 1 mM, 13.5-fold for cyclophosphamide at 0.01 mM and 1.5-fold for cisplatin at 0.1 mM. Surprisingly, MDA-MB-231 cells overexpres- sing MT4-MMP ...
HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins. By deacetylating histones and non-histone proteins, HDAC1 has a profound effect on t
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because of its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and the aim of this study was to clarified the mechanisms on early activation of HSF1 and ...
Erlotinib Response in a Non-Small Cell Lung Cancer Patient with EGFR Exon 20 MutationERLOTINIBADENOCARCINOMAEXONS (Genetics)EPIDERMAL growth factor receptorsPROTEIN-tyrosine kinasesThe article discusses a study on erlotinib response in a smoker Turkish male with metastatic lung adenocarcino...
When EGFRs increase above physiological levels, low doses of EGF are diluted among the receptors and the average phosphorylation per rececptor decreases. However, at high EGF concentrations, the ligand is no longer diluted, even at non-physiological levels of EGFR, and the average phosphorylation...
microtubule depolymerization and mitosis in tumor cells K Rea1, M Sensi2, A Anichini2, S Canevari*,1 and A Tomassetti*,1 FAK is a non-receptor tyrosine kinase contributing to migration and proliferation downstream of integrin and/or growth factor receptor signaling of normal and malignant cells...