Early changes in plasma EGFR mutation levels may indicate probable resistance patterns. Meaning Strategies to detect and target multiple coexistent resistance mechanisms will be needed to achieve more durable control of drug resistance in EGFR-mutant lung cancer....
In order to deepen the understanding of the functional meaning of HHLA2 in PC, the functional enrichment analysis for HHLA2-related gene sets in PC was performed. We first identified 918 differentially expressed genes (DEGs) between HHLA2-high and HHLA2-low expression groups using the E-MTAB-...
•Unliketheoverexpressionoftheimmunotherapytargethumanepidermalgrowthfactorreceptor2(HER2)inbreastcancerpatients,whichismostoftenconnectedwithanamplificationoftheHER2gene,thecorrelationofEGFRproteinlevelsandgeneamplificationandtheirmeaningforEGFRimmunotherapyresponseisstillcontroversial.AsalreadyshownforEGFRproteinexpression,we...
It is to be understood that the terminology used herein is for describing particular embodiments only and is not intended to be limiting. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to ...
PKCα、PCNA、GFAP、EGFR在脑胶质瘤中的表达及临床意义 【摘要】 目的 探讨蛋白激酶Cα、增殖细胞核抗原、胶质纤维酸性蛋白、表皮生长因子受体的表达、相互关系及其意义。方法 采用免疫组织化学法,检测55例脑胶质瘤标本中PKCα、PCNA、GFAP和EGFR的表达。结果 PKCα、PCNA和EGFR的表达随胶质瘤病理分级的增加而增高,而...
(Figure 2a) after circ_CHFR silencing, meaning that the interfering plasmid of circ_CHFR was successfully built. Subsequently, data disclosed that cell cycle arrested at G0/G1 phase after ox-LDL treatment in HBMECs, whereas this effect was attenuated by circ_CHFR silencing (Figure 2b). The ...
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the pr...
EPAS1和miR-200a调控非小细胞肺癌EGFR-TKI耐药性的机制研究摘要第一部分EPAS1通过EGFR和MET信号通路调控非小细胞肺癌TKI耐药性目的:肺癌已成为我国城市人口恶性肿瘤死亡原因的第1位的恶性肿瘤。非小细胞肺癌包括常见的鳞状细胞癌、腺癌、大细胞癌等,与小细胞癌相比其癌细胞生长分裂较慢,扩散转移相对较晚。非小细胞肺...
Curiously, SW756 and CaSki are the cell lines with the highest EGFR phosphorylation levels at basal conditions, meaning that they are hypothetically under EGFR control, and the quantity or time of EGF treatment was not enough to impact RKIP expression. To test this hypothesis, we treated the ...