Our 48-hour models were driven by a novel combination of features: patient-level (weight fluctuations over 365 days, depression symptoms, lab results, and cancer classifications), hospital-level (winter discharges and admission types), and community-level (zip code income brackets and partner ...
The samples with double or triple mutations have been further confirmed by independent DNA sequencing lab (data not shown). Discussion We tested 5125 Chinese NSCLC specimens for the somatic mutation frequencies of EGFR, KRAS, BRAF and PIK3CA. It was expected that somatic mutation testing from such...
These results illustrated that GC sr-exosomes contains EGFR oncoprotein, which may play an important role in the development of GC. The expression of HGF and c-MET in GC liver metastases. Although HGF has been reported to be upregulated in various types of cancer, the expression pattern of ...
Figure 1. Programmed death ligand 1 (PD-L1) tumor proportion score (TPS) immunohistochemistry (IHC) results in 71 lung adenocarcinomas. (A) Pie chart of PD-L1 IHC TPS. (B) Representative hematoxylin and eosin staining and PD-L1 IHC using clone 22C3 in different tumor materials: (1) cytol...
Observed TMB is dependent on characteristics of the specific tumor focus tested for a patient (e.g., primary vs. metastatic, tumor content) and the testing platform used for the detection; therefore, observed TMB results may vary between different specimens for the same patient and between ...
METHODS: The EGFR expression, amplification, and mutation in cervical carcinomas were assessed by immunohistochemistry, fluorescence in situ hybridisation, and PCR – SSCP, respectively, and correlated with clinical data collected by a retrospective chart review. A functional assessment was performed by ...
Results in Fig. 4E demonstrate that the indi- vidual effect of either PLD2 or PPARα + RXRα was positive on EGFR luciferase activity, while the effect was negated in the presence of PLD2 lipase inactive mutant K758R. We would expect to see a similar result in the ...
Results MiR-21 abundance contributes to the transition to a drug-tolerant persister state We leveraged an unbiased small RNA-sequencing (RNA-seq) approach in EGFR-mutant PC9 cells from an independent lab [45] to profile miRNA expression patterns. We found that miR-21-5p is the most abundant ...
2a). The enrichment results of proteomic data also showed the continuous upregulation of inflammation responses (such as granulocyte development and differentiation as well as CFTR activity), and suggested the downregulation of cytoskeleton regulation and platelet activation (Fig. 2b). At the ...
The parameter set with the eleven highest F1-score was taken as optimal solution, since it showed the highest sensitivity among the top results: Cresis ¼ 0.007, Cresp ¼ 0.02. Validation of the cetuximab response classifier. The cetuximab response classifier (16 genes) was validated on the...