6A). As expected, erlotinib treatment inhibited glucose carbon incorporation in M + 5 isotopologues, while PFKFB3 inhibition had no effect on glucose carbon incorporation in 5-CMP, guanosine, UTP, ADP nucleotide precursors (Fig. 6B, suppl. Figure 6 S). The erlotinib-mediated effect was ...
6A). As expected, erlotinib treatment inhibited glucose carbon incorporation in M + 5 isotopologues, while PFKFB3 inhibition had no effect on glucose carbon incorporation in 5-CMP, guanosine, UTP, ADP nucleotide precursors (Fig. 6B, suppl. Figure 6 S). The erlotinib-mediated effect was ...
In this study, we hypothesized that the breast tumor "intrinsic" subtypes might vary in dependence upon EGFR-signaling, which could be reflective of differences in gene expression patterns. Therefore, we used breast cell lines to identify an EGFR-pathway associated profile and examined interactions b...