Osimertinib shows higher effectiveness than first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in the initial treat... M Hibino,Y Imamura,R Shimoyama,... - 《Targeted Oncology》 被引量: 0发表: 2024年 Cost-Effectiveness of Osimertinib for EGFR Mutation–Posit...
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As shown in Supplementary Fig.4b, RIG-I protein levels were much lower from 12 h to 24 h after transfection with STAT3 in Huh7 cells than in control cells. In contrast, STAT3 overexpression did not affectRIG-ImRNA levels (Supplementary Fig.4c), suggesting that STAT3 may mediate RIG-I...
Previous publications have indicated that methods exhibiting increased selectivity facilitate the detection of a greater number of positive mutations in samples. For example, the percentage of positive mutations detected by PNA clamping (i.e., 18.84%) was higher than that of direct DNA sequencing (i...
NSCLC患者胸腔积液ROS1、EGFR基因突变与临床病理及靶向治疗的关系研究 作者简介:伍秉翔,男,副主任医师,主要从事肺癌临床方面的研究㊂ ә 通信作者,E -m a i l :b i n g x i a n g _w u @163.c o m ㊂㊃论 著㊃D O I :10.3969/j .i s s n .1672-9455.2023.15.025N S C L...
Considering that the recently introducedEGFR tests have a substantially higher sensitivity compared with direct sequencing, it is possible that additional lung cancers with a dual-positive status may be identified in the future. Therefore, we comprehensively investigated the prevalence of dual-positive NSC...
PFS and OS were also significantly lower among patients with primary resistance. In cohort A, patients with ex19del had a higher PFS (and presence of brain metastasis) than those with L858R. Hong et al. had previously described that L858R could have a negative prognostic value in NSCLC patien...
(χ2=4.56,P<0.05).Closecorrelationwasfoundontheexpressionof IGF-1Rbetweenpathologicalgradeofesophagealsquamouscarcinoma,theinvasion oftumorandTNMstages.Differencewasstatisticallysignificant.Theexpressionof IGF-1RorEGFRwashigherinlymphnodemetastasispositivepatientsthanthatin negativepatients.ConclusionTheexpressionofIGF...
it is noteworthy that its percentage to the total STAT3 phosphorylation was dramatically higher in low serum conditions, suggesting that this EGFR-mediated STAT3 phosphorylation may has a more potent role for cells in low serum conditions. Indeed, knockout of TMEM25 not only promoted cell proliferat...
Specifically, higher methylation levels of HOXB9 were associated with poorer responses to EGFR-TKI treatment.12 FTO, a N6-methyladenosine (m6A) eraser, was overexpressed during the development of resistant phenotypes when leukemia cells were treated by TKI therapy. In terms of mechanism, FTO-...