10.Lordick F,et al.Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer(EXPAND):a randomised,open-label phase 3 trial.Lancet Oncol.2013;14(6):490–499.doi:10.1016/S1470-2...
[6] Fukuoka S, et al. Regorafenib Plus Nivolumab in Patients With Advanced Gastric or Colorectal Cancer: An Open-Label, Dose-Escalation, and Dose-Expansion Phase Ib Trial (REGONIVO, EPOC1603). J Clin Oncol. 2020 Jun 20;38(18):2053-2061. doi: 10.1200/JCO.19.03296. Epub 2020 Apr 28. P...
2023年2月,刘炳亚研究员在《EBioMedicine》杂志在线发表题名为“VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer.”——VPS35通过EGFR再回收促进细胞增殖,提高胃癌中EGFR抑制剂...
TSPAN8EGFR/AKT signalingGastric cancerMigrationMetastasisTetraspanin 8 (TSPAN8), a transmembrane glycoprotein, is implicated in various pathological conditions including human malignancies. However, the roles and underlying mechanisms of TSPAN8 in promoting gastric cancer(GC)progression are yet to be fully...
cleavage of membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF), an EGFR ligand, induces translocation of the carboxyl-terminal fragment (CTF) of HB-EGF from the plasma membrane to the nucleus and regulates cell cycle.Two gastric cancer cell lines, MKN28 and NUGC4, were ...
Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. West China medical Virtual Journal, 2000, 1(1): -. doi: 10.1038/srep40802 Copy Previous Article Laparoscopic total pancreatectomy Case report and literature review WangXin,...
Similar results were found in gastric cancer. In a phase 2 clinical trial [21] patients whose tumors were refractory to 5-fluorouracil–based therapy, no significant progression-free survival (PFS) and overall survival (OS) benefit was found in the intent-to-treat population. As in the ...
EGFR靶向治疗癌症 CurrentstatusofEGFR-targetedcancertherapy PotentialtreatmentoptionsforEGFR-targetedtherapies Premalignancy Localizedtumors Locally/regionallyadvanced disease Advanced/metastatic disease SRT CT+RT CT EGFR-targetedtherapy S,Surgery;RT,Radiotherapy;CT,Chemotherapy/hormonetherapyEGFR,epidermalgrowthfactor...
(T-DXd, DS-8201), have been approved for the treatment of HER2-positive breast cancer and gastric cancers. However, T-DM1 showed limited effect for HER2-positive NSCLC patients, even in those with HER2-overexpressing NSCLC [216,217]. In contrast to T-DM1, in the DESTINY-Lung01 study, ...
Level I evidence in support of perioperative chemotherapy for operable gastric cancer: sufficient for wide clinical use? Ann Surg Oncol. 2007; 14: 2691-5.14. Briasoulis E, Liakakos T, Dova L, et al. Selecting a specific pre- or postoperative adjuvant therapy for individual patients with ...