This trial, held in 22 patients in Arizona, will assess PK and pharmacodynamics (PD') in brain tissue prior to a planned resection (surgery). If it is found that patients under this treatment with BDTX-1535 reach adequate drug levels in the gadolinium non-enhancing regions of the tumor, th...
Revascularization procedures in patients with ischemic cardiomyopathy are still uncertain regarding the usefulness of myocardial viability tests. The extent of myocardial scar, as measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR), was correlated with the diverse effects of ...
In the Phase 0 component of the study, total and unbound drug concentrations were measured in tumor tissue (gadolinium (Gd) enhancing and non-enhancing regions), cerebrospinal fluid (CSF), and plasma using validated LC-MS/MS methods. A PK 'trigger', defined as unbound drug concentration above...
2Citations Abstract Because of the nephrotoxicity of iodine-based contrast media and the more recently accepted role of gadolinium-based contrast media in the etiology of nephrogenic systemic fibrosis, the renal function of patients undergoing contrast enhanced imaging studies must be known so that, if...
The patients were positioned using the mask on a 1.5-Tesla magnetic resonance imaging (MRI) scanner, and gadolinium-enhanced T1-weighted MRI sequences were used to acquire localization images. After determining the BM treatment plan, CBCT was performed in Leksell Gamma Plan® to obtain ...
Because of the nephrotoxicity of iodine-based contrast media and the more recently accepted role of gadolinium-based contrast media in the etiology of nephrogenic systemic fibrosis, the renal function of patients undergoing contrast enhanced imaging studies must be known so that, if necessary, appropria...
Patel et al,29 2023 63, M Former tobacco use, hypertension, type 2 diabetes mellitus Large pericardial, cardiac MR imaging findings showed focal late gadolinium enhancement and myocardial edema 4 wks 666 pg/mL 2.2 ug/L 30-35 Initiated on empagliflozin, spironolactone, and metoprolol, discontinued...
injection of macrocyclic gadolinium chelate (Gadoteridol, ProHance) at a dose of 2.5 mmol Gd/kg body weight. Body temperature was maintained at 37 °C by blowing hot air into the magnet through a feedback control system. ∼12–15 min after injection of gadolinium, transverse T1-weighted ...
Yoon, Inflammation-specific T1 imaging using anti-intercellular adhesion mol- ecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid, Mol. ... The MICAD Research Team. In: Molecular Imaging and Contrast Agent Database - National Center for Biotechnology Information (US) 被引量: 55发...
(gadoliniumchelates)、毒素,如百日咳(pertussis)毒素、紫杉醇(taxol)、细胞松弛素b(cytochalasinb)、短杆菌肽d(gramicidind)、溴化乙锭(ethidiumbromide)、依米丁(emetine)、丝裂霉素(mitomycin)、依托泊苷(etoposide)、替诺泊苷(tenoposide)、长春新碱(vincristine)、长春花碱(vinblastine)、秋水仙碱(colchicine)、阿...