[4] Wang M, et al. Sunvozertinib for patients in China with platinum-pretreated locally advanced or metastatic non-small-cell lung cancer and EGFR exon 20 insertion mutation (WU-KONG6): single-arm, open-label, multicentre,...
本共识专家组系统检索和分析相关文献,使用关键词“非小细胞肺癌/Non-small cell lung cancer/NSCLC”、“EGFR exon 20 insertions/ EGFR ex20ins”、“EGFR tyrosine kinase inhibitors/ EGFR-TKIs”、“Mobocertinib”、“Amivantamab”...
[12]Sabari JK et al.,Amivantamab in post-platinum EGFR exon 20 insertion mutation non-small cell lung cancer.J Thorac Oncol 2021;16(3):S108-S109. [13]Doebele X,Riely GJ,Spira K,et al.First report of safety,PK,and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibit...
Title:Plasma ctDNA biomarker study in patients with non-small cell lung cancer with EGFR exon 20 insertion mutation treated with sunvozertinib 标题:接受舒沃替尼治疗的 EGFR exon20ins NSCLC 患者的血浆 ctDNA 生物标志物研究 讲者:北京协和医院 王孟昭教授 研究背景 关于EGFR exon20ins 的 NSCLC 的生物...
102605.Mobocertinib May Offer Effective, Safe Treatment in NSCLC with EGFR Exon 20 Insertion Mutation | IASLC.李汶倩,白日兰,崔久嵬.驱动基因阳性肺癌脑转移患者的靶向治疗进展[J].中国肺癌杂志,2019,22(11):719-726.Zhou C,Ramalingam S,Li B,et al.Mobocertinib in NSCLC with EGFR exon 20 ...
[5]Kwon C S , Lin H M , Crossland V ,et al.Non-small cell lung cancer with EGFR exon 20 insertion mutation: a systematic literature review and meta-analysis of patient outcomes[J].Current medical research and opinion, 2022(8):38. ...
Long-term survival after stereotactic body radiotherapy combined with immunotherapy plus anti-angiogenesis therapy in patients with advanced non-small cell lung cancer and EGFR exon 20 insertion mutation: a report of two cases. Transl Lung Cancer Res. 2023 Nov 30;12(11):2330-2341. doi: 10.21037...
21.Wang M, Fan Y, Sun M, et al. Sunvozertinib for patients in China with platinum-pretreated locally advanced or metastatic non-small-cell lung cancer and EGFR exon 20 insertion mutation (WU-KONG6): single-arm, open-label, multicentre, phase 2 trial. Lancet Respir Med. 2024;12(3):...
immunotherapy plus anti-angiogenesis therapy in patients with advanced non-small cell lung cancer and EGFR exon 20 insertion mutation: a report of two cases. Transl Lung Cancer Res. 2023 Nov 30;12(11):2330-2341. doi: 10.21037/tlcr-23-542. Epub 2023 Nov 20. PMID: 38090524; PMCID: PMC...
EGFR 20号外显子插入突变(exon20 insertion mutation,ex20ins)发生率居EGFR基因突变第3位,仅次于19号外显子缺失突变(ex19del)和21号外显子L858R点突变(L858R)。 携带EGFR ex20ins NSCLC患者的临床特征与EGFR常见突变患者类似,多见于亚裔、不吸烟的女性肺腺癌患者。与EGFR常见突变的患者比较,EGFR ex20ins患者整体...