在外显子19,我们共发现三种框架删除突变,其中最常见的是2235_2249delGGAATTAAGAGAAGC,它直接导致5个氨基酸的缺失(E746_A750del)。外显子18只检测到1例点突变,它导致第719位的甘氨酸为丝氨酸所替代(G719S)(附图)。突变相关因素 52例腺癌中23例发生突变(44.2%),15例腺鳞癌中3例突变(20%),在所有33例鳞癌和...
E746_A750del, L747_P753>S, T790M, L858R, L861Q and V600E mutations were higher in females than males, whereas G12C was higher in males than in females (Figure 3). Double mutations There were 153 patients found to have a double and coexisting mutation profile; 72.5% of them (111 ...
19号外显子的突变均为第746—753密码子的碱基缺失,以De1 E746一A75{)为主;21号外显子突变类型以L858R为主。女性EGFR基因的突变率显著高于男性,不吸烟者显著高于 吸烟者(P<005)。而EGFR基因的突变率与非小细胞肺癌患者的年龄、临床分期和淋巴结转移均无相关性(P>()05) 结论 湖南地区的非小细胞肺癌EGFR基因...
In the EGFR gene, the most prevalent mutation type was L858R (CTG>CGG) in exon 21, which accounted for 46.5% of all EGFR mutations. Del E746-A750 (K745:AAA), del E746-A750 (K745:AAG), del L747S752 ins S, del L747-E749 ins P and del L747-T751 were the ?ve major in-...
KRAS-mpu.Gtalnyt1c3aAsseps.(11.8%) Codon 12/13 mutation (10%) 12.3 mutation PatientID not detectedEGFR NGS (VAF) 1512m# utatiopn.E7n4o6t_Ad7e5t0edcetle(d40%) 1616# p.E746_A750del (58.9%) 34p26.E# 746_Am7u5t0at>ionDnPot(d2e.t6e%cte)d 3981# mutation not detected Ex19 ...