The bars with a rectangle box show the statistical difference of genotypes in percentage between smokers and non-smokers by the binomial test (P<0.001). Chart (A) and (B) share the same horizontal axis that represents genotypes. Full size image Significant associations were also found between ...
(number of genes) Pathways in cancer 18 genes Focal adhesion 11 genes MAPK signaling pathway 11 genes Regulation of actin cytoskeleton 9 genes ECM-receptor interaction 7 genes Tyrosine kinase receptor genes 2 genes (EGFR, c-MET) Figure 2 Flow chart depicting the strategy for identification of ...
Baseline creatinine and GFR values were assessed by chart review of patients’ medical records from hospital admittance data in the previous year. The primary outcome was in-hospital mortality, while ARDS development and need for non-invasive ventilation (NIV) and invasive mechanical ventilation (IMV...
Data were collected by chart review. Survival analyses were performed using the Kaplan鈥揗eier method using the log-rank test. (3) Results: A total of 131 patients were identified. The median age was 66. Thirty-three percent of patients had brain metastases. For the...
(F) Chart of number of tumor bearing mice in each group at day 15 and day 45. (G) Spider plots of tumor volume of HER2 Y772dupYVMA mice treated with indicated inhibitors. The red dotted line indicates the point of randomization (300 mm3)....
背景表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)疗法已成为晚期表皮生长因子受体(EGFR)突变型非小细胞肺癌(NSCLC)患者的标准治疗方式,但绝大部分接受EGFR-TKIs治疗的患者最终会出现获得性耐药。EGFR-TKIs联合抗血管生成药物治疗策略可能会延长患者生存时间。 目的探讨联合用药治疗晚期EGFR突变型NSCLC患者的临床疗效和安全...
(A) Flow chart of tumor inoculation and different treatments in Luc-Cal27 lung metastasis tumor model. Mice were treated with PBS, naked RNA (Let-7b mimics), NPs (NC), or NPs (mimics). (B) Bioluminescence images of the Luc-Cal27 lung metastasis tumor bearing mice at day 0, 7 and ...
Methods:Retrospective chart review of adult patients with EGFRm+ mNSCLC who received systemic treatment between January-2019 and June-2019. Results:A total of 162 patients were included from 21 hospitals, with a median follow-up of 15.6 months. Median age was 65.0 years, 22% had central ...
The livers of mice were pre-treated with HGF shRNA or HGF overexpressing lentivirus by multi-point injection, followed by orthotopic tumour implantation on the 6th day; finally, mice were killed and data were analysed on the 66th day. (a) A flow chart depicting the in vivo experimental ...
The mRNA expression in the candidate pathway was validated by RT–PCR and lncRNA/mRNA co-expression network was built to identify the correlated lncRNAs, which were subsequently validated by RT–PCR. The screening workflow chart was depicted in Supplementary Fig. 1. The detailed probe number and...