There were seven patients found to carry a triple mutation: four of them were male; two, smokers; age range, 47–76 years. There were five patients who harboured double EGFR mutations and one patient (76 years old, female) who had double PIK3CA mutations. Three triple-mutation specimens ha...
maintained by an inducible Tet-ON promoter35(Fig.2a). FLImP measures pairwise lateral separations between identical fluorophores with ~5–7 nm resolution, returning normalised distributions in the 0–60 nm range, which is ideal to investigate EGFR dimers and oligomers12. ...
A total of 682 patients (age range 23–100 years) were considered for statistical analysis, 310 needed mechanical ventilation and 137 died. An eGFR value <60 mL/min/1.73 m2 was found in 208 patients, 181 met KDIGO AKI criteria; eGFR values at hospital admission were significantly lower with...
“Amplifying,”“amplification,” and grammatical equivalents thereof refers to any method by which at least a part of a target nucleic acid sequence is reproduced in a template-dependent manner, including without limitation, a broad range of techniques for amplifying nucleic acid sequences, either ...
The median patient age was 60 years (range 26–84 years). The invasive adenocarcinomas/adenosquamous cell carcinomas con- sisted of 38 cases of stage I disease, 8 of stage II disease, 5 of stage III disease, and 1 of stage IV disease. All tumours were classified histologically according ...
17,18,19 It is well documented that inactivating mutations and downregulated expression or activity of TET proteins is closely associated with a wide range of cancers, including hematological malignancies and solid tumours.16,20 However, the function of TET proteins or their catalytic derivatives (e...
The screening workflow chart was depicted in Supplementary Fig. 1. The detailed probe number and ENST name was presented in Supplementary Table 2. Co-expression network and feed-forward loop prediction. For the co-expres- sion network, the system was built according to the normalized signal ...
The average PTEN IRS was 122 (range 0 – 300). Negative PTEN expression (IRSo60) was identified in 21.6% (n ¼ 59) of all tumours and was most frequently found in SDCs (41.7%), SQCCs (37.0%) and ACNOS (29.6%). Loss of PTEN expression was associated with advanced age (P ¼...
Nevertheless, when dealing with the real-world feasibility of molecular testing in an advanced setting, a retrospective observational chart review study including almost 3500 NSCLC patients initiating first-line systemic therapy between 2018 and 2020 in several US centers reported that <50% of them ...
After adjusting for age, we used a hierarchical binary logistic regression model to assess whether there was an interaction effect on the relationship between SUVmaxand EGFR mutations in different subgroups. The effect size with a 95% confidence interval was recorded. ...