The mean area under the curve at 110 mg daily was similar to 220 mg daily but with much lower incidence of creatinine phosphokinase (CPK) elevation (13.3% versus 51.6%) and diarrhea (6.7% versus 19.7%). The preliminary efficacy of 110 mg daily was 58.3% (21 of 36), and this was ...
6E-F). In addition, the levels of ALT, AST (hepatic function) and BUN, creatinine (renal function) showed that there was barely difference between the treatment and health groups (Fig. 6G-H). Collectively, these results indicated that the combination of fucoidan and sorafenib administration ...
Lactate dehydrogenase, creatine kinase, alanine transaminase, aspartate aminotransferase, creatinine, blood urea nitrogen, and spleen weight were not significantly altered by DPBA treatment. H&E staining of the kidney, spleen, liver, and heart revealed that DPBA had no significant toxic effects on any...
TAGRISSO in combination with pemetrexed and platinum-based chemotherapy: leukopenia, thrombocytopenia, neutropenia, lymphopenia, rash, diarrhea, stomatitis, nail toxicity, dry skin, and increased blood creatinine IN...
prevalence of eGFR under 60 ml/min per 1.73m2 in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and ...
Admission creatinine (mg/dl) 1.14 (0.84–1.5) 0.89 (0.73–1.10) >1.13 p < 0.001 Admission GFR (mL/min/1.73 m2) 53 (39–79) 81 (62–84) <60 p < 0.001 deltaGFR (mL/min/1.73 m2) 14.6 (3–26) 5 (0–18) >10 p < 0.001 AKI 71/137 (51.1 %) 110/545...
Patients with history of hypersensitivity to any active or inactive ingredient of HS-10296, interstitial lung disease, cardiac dysfunction, inadequate bone marrow function, altered liver enzymes or creatinine, and evidence of uncontrolled systemic or infectious disease were excluded. Patients were excluded...
metastasis, and adequate organ function as defined by a hemoglobin level of ≥ 9.0 g/dL, a neutrophil count of ≥ 1500/mm3, a platelet count of ≥ 100,000/mm3, serum transaminase levels of ≤ 100 IU/L, serum total bilirubin of ≤ 1.5 mg/dL, and serum creatinine of ≤ 1.5 mg/dL....