Product name: Anti-EGFR aptamer, Magnetic Cell Isolation Kit Catalog number: EGFR-2369BCI (biotinylated aptamer based cell isolation kit), EGFR-2369FBCI (bi-labeled aptamer based cell isolation kit) Content: EGFR-2369BCI (Biotinylated aptamer, streptavidin- coated magnetic bead and buffer), EGFR-...
The present invention concerns a nucleotide aptamer having the sequence 5′ GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC3′ (SEQ ID No. 1) for use in the treatment and/or prevention and/or diagnosis of an EGFR induced disorder and a pharmaceutical composition comprising the same. The invention also...
大家好,推荐一篇发表在ACS Chemical Biology上的文章,文章的题目是: A bivalent aptamer-based DNA agonist for EGFR signaling effectively alleviates ulcerative colitis in vivo。通讯作者是中山大学深圳校区药学院的李浩副教授、谢智勇...
This aptamer not only binds to EGFR-expressing cells but also inhibits receptor autophosphorylation and thwarts tumor cell proliferation in three-dimensional matrices, positioning it as a useful tool for tumor disease research [1]. 化学信息 分子量 406.44 分子式 C25H18N4O2 储存&溶解度 存储 ...
[0005]本发明涉及一种核酸适配体(Aptamer),其核苷酸序列如SEQ ID NO:1～4中的至少一项所示。 [0006]本发明还请求保护所述核酸适配体的的互补链。 [0007]根据本发明的再一方面,本发明还涉及用于分离EGFR或表面包含EGFR的物质的层析介质,所述层析介质包括基体支持物和固定于所述基体支持物上的配基,所述配基为如上...
Here, an aptamer, previously selected to EGFRvIII, was chosen as a lead compound for extensive post-SELEX maturation. The aptamer was 1.5-fold truncated, the ends of the hairpin stem were appended with GC-pairs to increase thermal stability, and single pyrene modification was introduced into the...
Current targeted therapies using small kinase inhibitors and antibodies have limited efficacy in treating prostate cancer (PCa), a leading cause of cancer death in American men. We have developed a novel strategy by engineering an RNA-based aptamer-siRNA
[0005] 肿瘤的靶向治疗需要与癌细胞特异结合的配体,除了抑制剂和抗体,在过去几十 年出现了新型肿瘤靶向配体如适配体(Aptamer),可作为肿瘤诊断和治疗应用中的靶向分 子。适配体又称为核酸适配体、适配子、配体,通常以长度为20‑100nt的随机核苷酸序列为 初始文库,是通过体外指数富集的配基系统进化技术(systematic ...
要求：1、文献中要有aptamer的明确序列；2、必须是DNA的aptamer；3、文献影响因子至少是4以上；...
Anti-EGFR aptamer exhibits direct anti-cancer effects in NSCLC cells harboring EGFR L858R mutations Brian J. Thomas Sania Z. Awan Donald H. Burke npj Precision Oncology(2024) The multiple roles of interferon regulatory factor family in health and disease ...