Furthermore, this hypothesis introduces the possibility of utilizing EGFR agonism as a potential therapeutic approach for the treatment of metastatic breast cancer.doi:10.1038/sigtrans.2016.42Remah AliMichael K WendtSignal Transduct Target TherSignal Transduction and Targeted Therapy...
The roles that EGFR and its ligands play in breast cancer have been a subject of intensive study and controversy. Some retrospective immunohistochemical studies have indicated that EGFR overexpression in primary tumors is an indicator of poor prognosis [44], [45], [46], [47], whereas other sim...
[8] Thigpen, T J. Randomized, Double-Blind Study of Denosumab Versus Zoledronic Acid in the Treatment of Bone Metastases in Patients With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma[J]. Yearbook of Medicine, 2011. [9] Overall survival improvement in patients with...
[3]Fisher B, Jeong JH, Bryant J, et al. Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. J Natl ...
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and ... Introduction Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation...
由ABCB1基因编码的P-gp和由ABCG2基因编码的乳腺癌耐药蛋白(breast cancer resistance protein, BCRP)为药物转运体中两种主要的外排型转运体。基于转运体对药物PK特征的影响,转运体抑制剂或诱导剂可能产生有临床意义的EGFR-TKIs药物相互作用。 (二)与吸收相关的药物...
EGFR基因多态性对乳腺癌新辅助化疗敏感性和毒性的影响(The impact of EGFR gene polymorphisms on the response and toxicity derived from neoadjuvant chemotherapy for breast cancer) 亮点 AME:为何开展本研究? 答:新辅助化疗通常用于治疗局部晚期乳腺癌。但是,并非所有患者都能达到病理完全缓解(pCR)。新辅助化疗后获...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis
WWOX is a tumor-suppressive steroid dehydrogenase, which relationship with hormone receptors was shown both in animal models and breast cancer patients. Herein, through nAnT-iCAGE high-throughput gene expression profiling, we studied the interplay of estrogen receptors and the WWOX in breast cancer cel...
EGFR has become an important target for the treatment of cancer, including non-small cell lung cancer, head and neck cancer, breast cancer, glioma, cervical cancer, and bladder cancer. First- to third-generation EGFR inhibitors have shown considerable efficacy and have significantly improved disease...