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Results show mean ± SEM. ∗, p < 0.05, Mann-Whitney test. (D) PCA of CAFs and malignant cells flow-sorted from vehicle- and ERBBi-treated PDAC tumors, as described in (A). (E) RNA-seq analysis of CAFs flow-sorted from ERBBi- (n = 4) or vehicle- (n = 4) treated PDAC ...
(iii) the partial desirability assessing the size effect of CvT is set to 1 when the effect size is higher the mean log fold-change (LFC) + 3 x standard deviation of the LFC and drops sharply to 0.01 if the LFC is lower than this boundary. This rule enables to give a high...
Pancreatic beta cell mass is dynamically regulated in response to increased physiological and pathological demands. Understanding the mechanisms that contr
Experimental data in a–c are reported as mean±s.d. from at least three independent experiments. Discussion The ubiquitination threshold is determined through a mechanism of 'coincidence detection' of two Tyr residues in the EGFR by a Grb2:Cbl complex. In this mechanism, two components are ...
This enterprise is highly reliant and reflective of shared norms, practices, and values (Kuhn, 1962). What comes to be accepted as a shared norm, practice, and value is likely to be influenced by the values that function as “presuppositions” (Hempel, 1965; Douglas, 2000, 2009) in ...
while the color scale shows predicted kinase activity (red—active; blue—inactive).FWestern blots of CDK2 in control and EMP3 KO cells.GQuantification of CDK2 band intensities (mean + S.D.) normalized to β-actin and calibrated relative to control cells (n = 3; Welch’s two-...
To further examine the biological importance of these three EGFR-associated gene sets, we individually applied them to a test set of breast tumors (i.e. the NKI295 sample set described in [33,34]) and determine whether they predicted patient outcomes. First, we determined a mean expression ...
Correspondence to Todd L. Edwards or Adriana M. Hung. Ethics declarations Competing interests The authors declare no competing interests. This publication does not represent the views of the Department of Veterans Affairs or the United States Government. Additional information Peer review information: Na...
1E, F). This correlation was observed regardless of the degree of risk (H: high; L: low) of disease recurrence and/or metastasis that was clinically prognosticated in Stage II CRC patients based on histopathological parameters. To further investigate the molecular mechanisms by which TAD and ...