We conducted an exploratory analysis to inform the clinical utility of EGFR mutation testing in blood cell-free DNA using the cobas (R) EGFR Mutation Test v2.Wu, Yi-LongLee, VictorLiam, Chong-KinLu, ShunPark, KeunchilSrimuninnimit, VichienWang, JieZhou, CaicunAppius, AnitaButton, Peter...
Blood, J Am Soc Hematol. 2015; 125(20):3133–43. CAS Google Scholar Mahajan K, Lawrence HR, Lawrence NJ, Mahajan NP. ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1. J Biol Chem. 2014; 289(41):28179–91. CAS PubMed PubMed...
Second, chemotherapy could affect EGFR mutation status, thus, the timing of tissue collection and peripheral blood collection matters the concordance rate. It is believed that Figure 3 | The summary operative receiver characteristic curve indicated high diagnostic accuracy (A, the area under summary ...
The inhibitory activity of compounds on growth was evaluated using the sulforhodamine B (SRB) colorimetric assay. Cells were seeded in 96-well plates, cultured overnight, and treated with a dilution series of test compounds for 72 h. Then, the SRB assay was performed according to standard proto...
HER2- XPAT and HER2-uTCE induced robust and comparable activation of intratumoral CD4+ and CD8+ T cells, whereas no trends for T-cell activation were apparent in blood samples in which HER2 was not present. Statistical differences in TGI and T-cell activation for test compounds versus vehicle...
Perform complete blood count with differential before starting TAGRISSO, periodically throughout treatment, and more frequently if indicated Verify pregnancy status of females of reproductive potential prior to initiating TAGRISSO. Advise pregnant women of the potential risk to a fetus. Advise females of ...
DNA from Formalin-fixed, paraffin-embedded tumor tissue and matched blood samples was extracted. Comprehensive genomic profiling was performed by NGS with a 37 or 450 cancer related gene panel covering the whole exons of EGFR gene at a mean coverage depth of >800X (1547 cases with 37 panel,...
K. et al. Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses. Clin. Cancer Res. 22, 1103–1110 (2016). Article CAS PubMed Google Scholar Kwak, E. L. et al. Irreversible inhibitors of the EGF receptor may circumvent acquired...
During surgery, the mean operation time was 2.4 h, with mean blood loss of 100 mL. All 33 participants who underwent surgical treatment received adjuvant treatment postoperatively, including target-therapy (n = 30) and immunochemotherapy (n = 3). Adjuvant immunochemotherapy for the...
(right) that are differentially expressed (the threshold of significance was defined by Po0.05 (with Student t-test) and the false discovery rate) in tumour-infiltrating CD4 þ T cells (T), paired peripheral blood CD4 þ T cells (P), and peripheral blood CD4 þ T cells from healthy...