(10))为对象,我们研究了EGF作用下,核内蛋白质与EGFR基因和c-fos,c-myc二种原癌基因的结合状态.研究发现,EGF的持续作用可使EGFR基因的特异结合蛋白质P120,c-fos基因的特异结合蛋白质P80,以及c-myc基因的特异结合蛋白质P125等明显增加.这些结果提示基因的特异结合蛋白质可能与EGF对基因转录的调控密切相关.上述结果...
Expression of c-Myc, TGF-alpha and EGF-receptor in sporadic medullary thyroid carcinoma. Acta Oncol 1997;36:407- 11.Wang W,Johansson HE,Bergholm UI.Expression of c-Myc,TGF-alpha and EGF-receptor in sporadic medullary thyroid carcinoma[J].1997,36(04)....
【结果】清燥救肺汤高,中剂量组EGF,ICAM-1,MMP2及TGF-α蛋白表达显著降低,与模型组比较,差异均有统计学意义(P〈0.05或P〈0.01);清燥救肺汤高,中,低剂量组c-myc蛋白表达显著降低,与模型组比较,差异有统计学意义(P〈0.05).【结论】清燥救肺汤可能通过降低EGF,TGF-α及c-myc,ICAM-1,MMP2蛋白表达,...
Stimulation of quiescent fibroblasts to growth by polypeptide growth factors is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes. In contrast to fibroblasts, A431 cells respond to epidermal growth factor (EGF) with a decreased growth rate. Here we report that, in spite of...
MiR-760 targets c-Myc to suppress fat metabolism [34], in addition to controlling cellular proliferative and migratory activity by targeting the BATF3/AP-1/cyclin D1 pathway [35]. MiR-760 has previously been reported to suppress G protein-coupled receptor kinase-interacting protein 1 expression...
<正> The decline of human gastric cancer BGC-823 cells’ proliferation and the responsiveness to epidermal growth factor, following down regulation of c-erbB-2 expression by the antisense recombinant vector, was observed . The induction of cell proliferation, c-myc gene expression and expression ...
Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells Cancer Res., 64 (2004), pp. 463-467 View in ScopusGoogle Scholar Yuan et al., 2004 X. Yuan, J. Curtin, Y. Xiong, G. Liu, S. Waschsmann-Hogiu, D.L. Farkas, K.L. Black, ...
百度试题 结果1 题目根据权利要求1所述的用途,其中,所述生物标志物为EGFL7、Notch3、EGFR、β-catenin和c-Myc。相关知识点: 试题来源: 解析 用无血清培养基,按1:8(Matrigel:无血清培养基)的体积比稀释Matrigel。反馈 收藏
(B) LAPTM4B is co-IP’ed with not only EGFR but also PDGFRB, FGFR2, and c-Met. Myc-LAPTM4B was co-transfected with indicated receptor constructs into HEK293 cells. Each receptor expresses a C-terminal GFP tag and was IP’ed by anti-GFP. (C) Serum starvation does not affect LAPT...
The different patterns of the concentration change vs time curves of c-K-ras-P-IR, rEGF-IR and hst-1/k-FGP-P-IR in regenerating rat liver together with those of c-myc, c-fos and RE gene products immunologically measured in our previous studies suggest significant participation of these ...