Trans-interaction between EphB4 and its membrane-bound ligand ephrin B2 (EFNB2) mediates bi-directional signaling: forward EFNB2-to-EphB4 signaling suppresses tumor cell proliferation, while reverse EphB4-to-EFNB2 signaling stimulates the invasive and angiogenic properties of endothelial cells. ...
We used the autochthonous RIP1-Tag2 model of tumor angiogenesis, to study the effects of 1) inhibition of Dll4/Notch by either allelic deletion or use of a soluble extracellular Dll4 (Dll4-Fc), and 2) inhibition of EfnB2/EphB4 signaling by a soluble extracellular EphB4 fused to albumin...
Ephrin-B2 (EFNB2); EPH receptor B4 (EPHB4)Studies in mice suggest that inhibiting EFNB2 activity may be useful for treating Kaposi's sarcoma.Springer NatureScience-Business eXchangedoi:10.1038/scibx.2008.922
The expression levels of EPHB4 and EFNB2 were positively correlated with each other, whereas the mRNA levels of both EPHB4 and EFNB2 exhibited a negative correlation with that of caspase-8. The mRNA levels of both EPHB4 and EFNB2 demonstrated a significant positive association with certain ...