The efficacy‐effectiveness (EE) gap describes the differences in survival seen in clinical trials and routine clinical practice, where patients in real‐world practice often have inferior outcomes compared to trial populations. However, EE gaps may exist beyond survival outcomes, including gaps in ...
clinical trials for group B RBCs, a major obstacle in translating this technology to clinical practice has been the lack of efficient glycosidase enzymes. ... QP Liu,G Sulzenbacher,H Yuan,... - 《Nature Biotechnology》 被引量: 335发表: 2007年 Effectiveness of a strategy to improve adherence...
This paper describes a large case study that explores the applicability of ontologies and semantic technology to problems in the medical domain. We investigate whether it is possible to use ontologies to automate common clinical tasks th... C Patel,J Cimino,J Dolby,... - International the Seman...
Hence, data are difficult to interpret and efficacy does not always correspond to real-world effectiveness. We investigated to what extent an efficacy-effectiveness gap exists for OMPs for metabolic diseases and set out to explore which factors contribute to it. Methods We included all OMPs for ...
D. (2007). Clinical trials: Bridging the gap between efficacy and effective- ness. International Review of Psychiatry, 19, 531- 539. doi:10.1080/09540260701563320Depp C, Lebowitz BD: Clinical trials: Bridging the gap between ef- ficacy and effectiveness. Int Rev Psychiatry 19:531-539, 2007....
323: METHODS FOR QUANTIFYING EFFICACY-EFFECTIVENESS GAP OF RANDOMIZED CONTROLLED TRIALS323: METHODS FOR QUANTIFYING EFFICACY-EFFECTIVENESS GAP OF RANDOMIZED CONTROLLED TRIALSdoi:10.1097/01.ccm.0000551077.93842.20Mohammad AdibuzzamanYonghan JungElias BareinboimPaul...
Bridging the efficacy-effectiveness gap: a regulator's perspective on addressing variability of drug response. Drug regulatory agencies should ensure that the benefits of drugs outweigh their risks, but licensed medicines sometimes do not perform as expected in everyday clinical practice. Failure may ...
Factors Contributing to the Efficacy-Effectiveness Gap in the Case of Orphan Drugs for Metabolic Diseases 喜欢 0 阅读量: 30 作者:Gispen-de Wied,C. C.,Stoyanova-Beninska,V.,Biegstraaten,M.,Hollak,C. E. M.,Schuller,Y.摘要: Introduction Authorization of orphan medicinal pro ...
“Our next steps will be to identify the key contributors to the efficacy-effectiveness gap within our Ontario population so that we can work toward overcoming them. But what we need is for future trials to be more pragmatic in their trial design and more inclusive ...
Assessing the efficacy-effectiveness gap for cancer therapies: A comparison of overall survival and toxicity between clinical trial and population-based, real-world data for contemporary parenteral cancer therapeutics. Cancer. 2020;126:1717–26. Article PubMed Google Scholar Srikanthan A, Vera-Ba...