Kruse-Jarres R, St-Louis J, Greist A, et al.: Efficacy and safety of OBI-1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A. Haemophilia. 2015, 21:162-170. 10.1111/hae.12627
Toxicity was as expected, largely of grade (G) 1-2, always reversible and mainly consisting in: infusion reactions (G1-2 92%; G3 4%, in a single pt allergic to previous RTX who discontinued OBI); asymptomatic increase of liver enzymes (G1-2 19%; G3 GGT 15%; G3 ALT 4%); ...
This review attempts to bring together information from a large number of recent studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is widely used in many countries for the relief of symptoms of pain, inflammation and fever. The evidence for modes of action...
Journal of Cancer Research and Clinical Oncology (2021) 147:3025–3042 https://doi.org/10.1007/s00432-021-03759-4 REVIEW – CLINICAL ONCOLOGY Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases Catalina Hoppe1 · Maren ...
This randomized clinical trial examines the safety, efficacy, and feasibility of intranasal insulin for the treatment of persons with mild cognitive
The objectives of this study were to evaluate the efficacy and safety of two doses of safinamide (50 and 100 mg once daily for 24 weeks) as an add-on therapy to l-DOPA compared with placebo in PD patients with wearing-off. 2. Materials and methods 2.1. Study design This was a 24-...
We conducted a multi-arm, randomized, double-blind, placebo-controlled trial in 336 infants aged 5–12 months to determine the safety, tolerability, immunogenicity and efficacy of the PfSPZ Vaccine in infants in a high-transmission malaria setting in western Kenya (NCT02687373). Groups of 84 ...
LBA1 Efficacy and safety of DuodartTM treatment versus watchful waiting (WW) with step-up therapy to tamsulosin in the management of men with treatment-naïve, prostate enlargement, increased prostate-specific antigen (PSA) and moderately symptomatic benign prostatic hyperplasia (BPH): 2-Year CONDUC...
ClinicalTrials数据库提供临床试验Study on the Efficacy and Safety of a Novel Tripterygium Wilfordii Preparation in Reducing Proteinuria in Patients With Diabetic Nephropathy的登记号NCT04981613,试验分期N/A以及申办者First Affiliated Hospital Xi'an Jiaotong
The effectiveness and safety of anticancer therapy can be significantly influenced by different active compounds not only included in the daily diet but also in dietary supplements, which play crucial roles in modulating the activity of multidrug resistance (MDR) transporters. These transporters, such ...