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Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnine inhibited the CBF increase caused by glycine injection into the brain. Induction of c-Fos expression was observed in the hypothalamic nuclei, including the medial ...
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2002, Psychopharmacology Apomorphine, d-amphetamine, strychnine and yohimbine do not alter prepulse inhibition of the acoustic startle reflex 1988, PsychopharmacologyView all citing articles on Scopus☆ Primary funding for this research project was provided by the Office of Research and Development, Environ...
Stimulation of other modulatory sites on the NMDA receptor offer safer alternatives. Endogenous glycine and D-serine both act as co-agonists at the strychnine-insensitive glycine-B (Gly-B) site on the NMDA receptor, and along with glutamate, co-activate the receptor (Dingledine et al, 1990; ...
PJ Birch CJ Grossman AG Hayes (1988)Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptorEur J Pharmacol15485–8710.1016/0014-2999(88)90367-628463281:CAS:528:DyaL1cXls1entrg%3D ArticlePubMedCASGoogle Scholar ...
for its inclusion of poisonous substance strychnine that caused convulsions, hallucinations, and heart and kidney failure [35]. More recently, Yohimbine was detected in a product labelled as OxyELITE Pro and sold online as slimming pills. This caused the hospitalisation of two female patients aged ...
Purpose: Although vagus nerve stimulation (VNS) is now marketed throughout most of the world as a treatment for drug-resistant epilepsy, the therapeutic mechanism of action of VNS-induced seizure suppression has not yet been established. Elucidation of this mechanism is an important first step in...
d. Long-term anticonvulsants for the treatment of generalized tonic-clonic and cortical local seizures. And, in the emergency control of certain acute convulsive episodes, e.g., those associated with status epilepticus, cholera, eclampsia, meningitis, tetanus, and toxic reactions to strychnine or ...
Further, some antagonists of strychnine-insensitive glycine modulatory sites among the NMDA receptor complex (e.g., L-701,324) dose-dependently substitute for the ethanol discriminative stimulus. On the other hand, neither GABA鈥揵enzodiazepine antagonists nor NMDA receptor agonists produce contradictory...