Ovarian cancerApoptosisSignaling pathwaysOvarian cancer is one of the main causes of women's mortality worldwide. A variety of biological mechanisms are involved in ovarian cancer pathogenesis, including epigenetic alterations, mutations (especially in tumor suppressor genes), upregulated oncogenes, ...
Relates the author's experience in witnessing how his wife died from the adverse effects of various treatments for ovarian cancer. Observation of the recurrence of cerebral metastasis via the enhanced magnetic resonance imaging; Wife's white matter disease resulting from Whole Brain Radiation and the...
Ovarian cancer is one of the three most common gynecological malignant tumors. The mortality rate of ovarian cancer is high because of the insidious disease onset and the lack of effective methods for early diagnosis. In this study, we assessed the potential of SPOCK1 as a significant biomarker...
HMGA2 can promote malignant transformation of ovarian cancer cells, enhance cell invasion and metastasis, and promote cell growth and proliferation of ovarian cancer cells, which can cause ovarian cancer to progress rapidly and affect the quality of life. 展开 关键词: High;mobility;group;AT-hook;...
Purpose:To study the effects of arsenic trioxide on the different types of human ovarian cancer cells growth in vitro.Methods:Methyl thiazolyl tetrazolium (MTT)was used to observe the growth inhibition rates of human ovarian cancer cell lines 3AO,SKOV 3 and TYK cells by various concentration arse...
- 《Journal of the National Cancer Institute》 被引量: 0发表: 2001年 Effects of Retinoids on Cancerous Phenotype and Apoptosis in Organotypic Cultures of Ovarian... Investigates the effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma in the United...
and letrozole plus tamoxifen on the growth and drug resistance of cisplatin-resistant human ovarian cancer cell line SKOV3/DDP.Results:Different concentrations(1×10-9 mol/L-1×10-4 mol/L) of letrozole and low concentration tamoxifen had no impact on the growth of SKOV3/DDP cells,which ...
has identified the mechanism of action of PARP inhibitors, used in particular for breast and ovarian cancer in patients carrying the BRCA gene mutation. These inhibitors block two specific activities of the PARP proteins. By blocking one of them, the toxic effect on cancer cells is maintained, ...
Women diagnosed with ovarian cancer or breast cancer often face aggressive chemotherapy involving multiple treatment regimens. These treatments may be associated with significant side-effects that adversely impact patient quality of life. In this review, we will highlight recent research on side-effects ...
(a) the effect of false-positive breast and ovarian cancer screening test results on perceived cancer risk and cancer worry, and (b) the joint effects of FPTR, risk perceptions, and worry on the choice of risk-reducing surgery among BRCA1/2 mutation carriers undergoing an intensive cancer ...