Avida is a computer program that performs evolution experiments with digital organisms. Previous work has used the program to study the evolutionary origin of complex features, namely logic operations, but has consistently used extremely large mutational
Increasing evidence suggests that urbanization is associated with higher mutation rates, which can affect the health and evolution of organisms that inhabit cities. Elevated pollution levels in urban areas can induce DNA damage, leading to de novo mutations. Studies on mutations induced by urban ...
The complexity of small molecule chemistry and binding interactions has hindered the development of methods to assess the effects of mutations. This is compounded by the multitude of effects on stability and interplay with partners that mutations trigger in proteins. However, obtaining mathematical repres...
ARTICLES Effects of G-protein mutations on skin color Catherine D Van Raamsdonk1, Karen R Fitch1, Helmut Fuchs2, Martin Hrabe´ de Angelis2 & Gregory S Barsh1 A new class of dominant dark skin (Dsk) mutations discovered in a screen of B30,000 mice is caused by increased dermal ...
In their structural interaction network, Wanget al.found that proteins that interact with one another are more likely to cause the same disease than expected at random, with mutations on the corresponding interfaces more likely to cause the same disease than those on non-interacting interfaces on ...
Principal irradiation effects were reduction in litter size and reduction in population numbers. Both are attributed to radiation- induced lethal mutations. The critical mutation rate is thought to have been approached. (auth) 展开 关键词:When tomatoes were planted in steamed soil inoculated with ...
Finally, we constructed an independent test dataset listing the effects of 3,749 mutations on the stability of the SARS-CoV-2 spike protein and the effect of 3,669 mutations on its affinity to the human ACE2 receptor.52 Table 1. Datasets used to train, validate, and test the EL2core ...
organisms (Rogers and Wood2004; Atli and Canli2007; Mahmut et al.2022; Sevgiler and Atli2022). It was concluded that Zn2+may have inhibited Ca2+-ATPase activity by competing with Ca2+for the Ca-selective channel, which caused an ion disruption (Heath1995). Zn2+has an inhibitory effect ...
The frequency of double mutations (individuals containing both the A302S and R300Q mutation) is also illustrated. (C) The effects of synergists on fipronil resistance ratios are illustrated in insect populations isolated during various generations of selection. ligand-gated chloride channels that ...
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims t