The contributions of gonadal steroids to coronary risk in men have received less attention. This chapter reviews the effects of androgens and estrogen on plasma lipids and relates these data to the increased coronary risk associated with male gender....
Supernumerary sex chromosome aneuploidies (sSCA) are characterized by the presence of one or more additional sex chromosomes in an individual’s karyotype; they affect around 1 in 400 individuals. Although there is high variability, each sSCA subtype has a characteristic set of cognitive and physical...
There is a slightly increased risk ofblood clotsin those who take a combination estrogen and progestin birth control;17however, other factors can contribute to risk, such as age, weight, and family history. Progestin-only types of birth control do not increase the risk of blood clots.1 Possib...
To avoid confounding, 117 women taking estrogen were excluded from analysis. Both sexes experienced reductions in disease progression with lovastatin; there was no evidence of an overall sex x treatment interaction (P=0.72). When estimates of the sex-specific results were examined post hoc, women ...
their sexual maturity. This highlights the importance of taking into account the combined effect of genetics, sex and developmental stage. Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters...
Testosterone administration in humans modulates, for instance, striatal activity during reward processing in women12, insular activity during risk-taking in men13, and amygdala activity in women when responding to social threats14,15. Furthermore, modulated amygdala−prefrontal coupling was observed ...
The ovaries produce both testosterone and estrogen; as they age, they have less estrogen and testosterone. As women enter peri-menopause and pre-menopause, testosterone will be diminished by the age of the ’30s. Once a women reach full menopause, it’s common for them to produce 75% less...
might have the potential risks of abuse and neurotoxicity [20]. Taking these factors into consideration, esketamine, the (S)-enantiomer of ketamine, was only approved for patients with treatment-resistant depression (TRD) or suicidality by the US Food and Drug Administration (FDA) in 2019. ...
paradigm to test the effect of a systemic blockade of Nk3R during memory consolidation. Further, we assess the expression of estrogen receptor α, estrogen receptor β, and androgen receptor and heterodimerization with Nk3R in the medial prefrontal cortex (mPFC) and dorsal hippocampus (DH) of ...
Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effectsDocosahexaenoic acid concentrations are higher in women than in men because of estrogenic effectsn−3 Fatty acidsdocosahexaenoic acidestrogen administrationtestosterone...