Advances in Chronic Kidney DiseaseAlicic RZ, Patakoti R, Tuttle KR. Direct and indirect effects of obesity on the kidney . Adv Chronic Kidney Dis . 2013; 20 :121-7. PubMed Abstract Publisher Full TextA
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalan...
Overall hemodynamic effects on arterial stiffness and nocturnal blood pressure play an important role in the pathogenesis of hypertensive heart disease. Therefore, these could represent mechanistic targets underlying the effects of angiotensin receptor–neprilysin inhibitors on the continuum of cardiovascular ...
6 The same group reported that the HIF-PHD inhibitor FG4592 exerted limited effects on the development of fibrosis in a unilateral ureteral occlusion model.7 In the case of autosomal dominant polycystic kidney disease, inhibition of PHD by FG2216 accelerated cyst growth.8 Conversely, a study ...
What are the effects of chronic kidney disease on the quality of life of an individual? How could chronic kidney disease cause low urine output? What brings blood to the kidney? What happens during the process of renal secretion? What are the functions performed by the kidneys?
the combination of neurologic andliverdisease (Rosencrantz and Schilsky, 2011, pg. 246) and by Dr Adolph Strümpell in 1898, who noted hepatic cirrhosis. In 1948, a professor by the name John N. Cumings made the link with copper accumulation in both the liver and the brain (News-Medical...
Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease View LargeDownload Figure 1. Flowchart of Trial Participants View LargeDownload Figure 2. Effect of Time-Restricted Eating (TRE) vs Daily Calorie Restriction (DCR) on the Intrahepatic Triglyceride (IHTG) Content View LargeDownload ...
Yellowing of your skin or the whites of your eyes Severe nausea or vomiting Pain on the right side of your stomach area (abdomen) Dark urine (tea colored) Bleeding or bruising more easily than normal Kidney problems: Decrease in your amount of urine Blood in your urine Swelling of your ank...
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populat
After controlling for demographics, CSA in women was found to be associated with cardiac problems, hypertension, gastrointestinal disorders, hernia, ulcer, and kidney/liver disease. However, when childhood physical abuse and neglect were also controlled for, only cardiac problems were uniquely associated...