These results suggest that histamine has facilitatory and depressant actions on ACh release. The facilitatory action is probably mediated by the H 1-receptor and the depressant action by the H 2-receptor, both of which are located at the presynaptic nerve terminals of bullfrog sympathetic ganglia....
F. Sewing. Effects of histamine and activators of the cyclic AMP system on protein synthesis in and release of high molecular weight glycoproteins from isolated gastric non-parietal cells. Br. J. Pharmacol. 104: 526-530, 1991.Heim, H. K., Oestmann, A. and Sewing, Fr. K. (1991) ...
1 In this study we have evaluated the possible contribution of acetylcholine release in histamine‐induced contractions of guinea‐pig large and small intestinal smooth muscle. Moreover, the presence of the histamine receptor types involved in smooth muscle relaxations and inhibition of electrically‐indu...
How is a histamine reaction stopped? The histamine reaction can be controlled by avoiding the food that contains a high level of histamine or the food that prompts the histamine release. The food that prevents the activity of the diamine oxidase enzyme has to be avoided. Instead, the consumptio...
Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and n... We have compared the ability of anti-IgE, calcium ionophore A23187, substance P, compound 48/80, poly- l-lysine, and morphine to ...
1. Substance P (SP) induces histamine release from isolated rat peritoneal mast cells at concentrations of 0.1-10 muM.2. Inhibitors of glycolysis and oxidative phosphorylation prevent the release of histamine induced by SP.3. Cells heated to 47 degrees C for 20 min release histamine when treated...
The effects of dasatinib were dose-dependent (IC50: 50-500 nM) and specific for FcϵRI activation in that the drug failed to inhibit C5a-induced or Ca-ionophore–induced histamine release. Interestingly, at lower concentrations, dasatinib even promoted FcϵRI-dependent histamine release in ...
The effects of histamine, thioperamide and EEDQ ( N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline) at the noradrenaline release-modulating H 3 receptor in the mouse brain were examined. In superfused mouse brain cortex slices preincubated with 3 H-noradrenaline, the inhibitory effect of histamine...
The histamine releasing action of anandamide and the enhancing effects of WIN 55,212-2 and HU-210 on anti-IgE-induced histamine release were not reduced by the cannabinoid receptor antagonists, AM 281 and AM 630. In conclusion, the present study does not support the hypothesis that cannabinoids...
In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin Mast cells from different anatomic sites differ in cytochemistry and response to various secretory stimuli. We have investigated whether responsiveness to ... Y Okayama,RC Benyon,MA...