Estrogen exerts its effects on the CNS via nuclear and "membrane" receptors that are widely distributed throughout the CNS. These effects include protection against oxidative stress and apoptosis. These effects influence the membrane fluidity, ionic conductance expression of growth factors, and metabolic...
These effects include activation of the nuclear estrogen receptor, altered expression of bcl-2 and related proteins, activation of the mitogen activated kinase pathway, activation of cAMP signal transduction pathways, modulation of intracellular calcium homeostasis, and direct antioxidant activity. 展开 ...
But sparse estrogen sensitive cells were also observed in other parts of the brain, for example in the hippocampus, the midbrain, and the brainstem. They were so few and far between that they were generally ignored at that time. Many years later in my own lab, we went back to the ...
Brann D: Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 2007, 72(5):381–405. 10.1016/j.steroids.2007.02.003 Article CAS Google Scholar Craig MC, Fletcher PC, Daly EM, Rymer J, Brammer M, Giampietro V, Murphy DGM: Physiological variat...
It also has estrogenic effects, meaning that it mimics the effects of estrogen in the body. If you have hormone-sensitive conditions, such as uterine fibroids, endometriosis or ovarian cancer, you should consult with your healthcare professional before starting supplementation. ...
Cyclical hormone flux—and perimenstrual E2 and P4 withdrawal specifically—appears to contribute to the perimenstrual exacerbation of SI, planning, and related symptoms in cycling patients. Current standards of care for suicidality do not include assessment of cyclical symptom changes, and no diagnostic...
Outbreak risk models of rodent pests often do not include sufficient information regarding geographic variation. Habitat plays an important role in rodent-pest outbreak risk, and more information about the relationship between habitat and crop protection is urgently needed. The goal of the present ...
In vitro studies suggest that estrogen suppresses MGL activity in adipocytes, indicating that estrogen might interfere with MGL-TRβ function. Compared to systemic adiposity, HFD reduced bone mass in male but not female mice. Paradoxically, MGL treatment reversed macroscopic bone mineral density loss ...
Yang LC, Zhang QG, Zhou CF, Yang F, Zhang YD, Wang RM, Brann DW: Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus. PLoS One. 2010, 5 (5): e9851-10.1371/journal.pone.0009851. Article PubMed PubMed Central Google Scholar Sun X, Zho...
In this study, we used the random amplified polymorphic DNA (RAPD) assay to evaluate the effects on the genomic DNA of barnacle larvae that had been exposed to 17β-estradiol (E 2) and low concentrations of 4- n-nonylphenol (NP). DNA effects include DNA damage as well as mutations and...