However, it's still unclear how the long-term and sustained cocaine exposure will affect clock genes' expression in the reward related brain areas. We hypothesize that chronic cocaine exposure causes changes in the circadian rhythmic expression of clock genes in brain regions associated with reward,...
Coroner's spokesman Craig Harvey says cocaine metabolites were found in Houston's system, and it was listed as a contributing factor in her death. He says the results indicated Houston was a chronic cocaine user.
Chronic cocaine administration: sensitization and kindling effects. In: Raskin, A., Fisher, S. (Eds.), Cocaine: Clinical and Biobehavioral Aspects. Oxford University Press, New York, pp. 109-173.Post, R.M., S.R.B. Weiss, A. Pert and T.W. Uhde, 1987, Chronic cocaine administration: ...
Although the mechanism underlying these behavioral effects has yet to be established, our results indcate that inherent alterations can differentially affect both acute and chronic susceptibility to the behavioral effects of amphetamine and methylphenidate. Use of such altered strains of mice can be ...
According to the 1988 National Household Survey conducted by the National Institute on Drug Abuse, cocaine use among the total population has decreased. This same survey also reported an increase in cocaine use among chronic abusers of the drug. As cocaine use has increased among the abuser popula...
Cocaine also constricts blood vessels locally, and is sometimes used off-label to stop nasal bleeding temporarily, before cauterization or packing. Other than its only approved clinical use, cocaine is abused and misused illegally because of its central nervous system (CNS) effects. ...
of the mechanism(s) of indirect sympathomimetic drugs like amphetamine can be obtained from the use of cocaine. Cocaine inhibits the reuptake of noradrenaline into neuronal cells. Therefore, cocaine increases the effects of noradrenaline on the heart by increasing the concentrations of noradrenaline ...
S. Effects of chronic social stress during lactation on maternal behavior and growth in rats. Stress 14, 677–684 (2011). Article PubMed PubMed Central Google Scholar Miczek, K. A., de Boer, S. F. & Haller, J. Excessive aggression as model of violence: a critical evaluation of ...
Historical data concerning the use of cocaine, its epidemiology, chemistry and pharmacology, as well as its medical complications and treatment, in both acute intoxication and chronic addiction is reported. Its repercussion and damage upon the nervous system with neurologic and psychiatric alterations is...
Pharmacological treatments that alter dopaminergic functioning have not lessened cocaine use in addicted patients. Non-dopaminergic mechanisms may therefore be important in the chronic use of cocaine. Procaine, like cocaine, is a local anesthetic, but has only 1% of cocaine's affinity for the dopamine...