Thus, CBD might treat not only seizures but also some of the comorbidities associated with seizures. The present study was designed to test the effects of THC, CBD and a combination of CBD and THC (15:1 ratio) in a mouse of depression (the forced swim test, FST). Previously we had ...
Consumption of the Cannabis edible dates backs to several years ago. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are compounds found naturally in plants that aregenus Cannabis, they both have similar chemical structures but they only differ in their arrangement. They cause really different effect...
Adult neurogenesis is the process by which new neurons are generated within specific brain niches throughout the life of an organism. Neurogenesis seems to be ubiquitous to all species with a central nervous system (CNS) (Barker et al.2011), and for many of them, the process is confined to...
THC: CBD Nabiximols (Sativex) is a specific plant extract with an equal ratio of THC: CBD. It is approved as a drug in the UK and elsewhere in Europe for the treatment ofmultiple sclerosis, spasticity,neuropathic pain,overactive bladder, and other indications. Medical marijuana products are ...
Cannabidiol (CBD), a significant phytocannabinoid from the Cannabis sativa plant, has recently gained considerable attention for its wide-ranging therapeutic potential and its apparent absence of psychoactive effects [1, 2]. Unlike tetrahydrocannabinol (THC), another well-known cannabis component known ...
2022). However, no study to date has examined the effect of selective CB1R NAM for the treatment of acute and protracted opioid withdrawal symptoms. Cannabidiol (CBD), which has a diverse range of pharmacological actions (Martin et al. 2021), including CB1R negative allosteric modulation (La...
“CBD by itself had no effect,” says lead author Roger Hudson, explaining one of the more interesting elements of the research. “However, by co-administrating CBD and THC, we completely reversed the direction of the change on a molecular level. CBD was also able to reverse the anxiety-li...
Given the emerging evidence that TRPV1 channels—a major CBD target—are estradiol-modulated (Yamagata et al, 2016), examining sex differences in a variety of CBD effects is warranted. Finally, it should be noted that to date, only a few laboratories have examined sex differences in either ...
with high levels of THC and low levels of CBD have increased neuropsychiatric effects, but the exact relationship between CBD and THC was not understood. Hudson et al. investigated the role of the protein ERK, which triggers a signaling pathway implicated in the neuropsychiatric e...
. Few cannabinoids have been compared in femalesvsmales using models of persistent pain, which are likely to be more predictive of cannabinoid analgesic potential in humans. In the complete Freund’s adjuvant (CFA) model of paw inflammatory pain, systemically administered THC produced greater anti-...