The two most widely studied ALS/FTLD models, super-oxide dismutase 1 (SOD1) and TAR DNA binding protein of 43 kDA (TDP-43), reveal metabolic dysfunction and a positive effect of metabolic strategies on disease onset and/or progression. In addition, molecular studies reveal a role for ALS/...
Respiratory muscle involvement is one of the main prognostic factors in amyotrophic lateral sclerosis (ALS). Acute respiratory failure is sometimes the first manifestation of the disease, although onset can be more insidious. In the present retrospective study, it was proposed to review the clinical ...
In urban economically distressed communities, high rates of early sexual initiation combined with alcohol use place adolescent girls at risk for myriad neg... - 《Journal of Adolescent Health Official Publication of the Society for Adolescent Medicine》 被引量: 66发表: 2008年 Centers for Disease Co...
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases, autoimmune diseases, cardiovascular disease...
have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome) have allergies to any botulinum toxin product had any side effects from any botulinum toxin product in the past ...
To evaluate the relevance of this neurotoxic mechanism in ALS pathology, we assessed the therapeutic potential of FPS-ZM1 in hSOD1G93A mice. FPS-ZM1 treatment significantly improved hind-limb grip strength in hSOD1G93A mice during the progression of the disease, reduced the expression of ...
www.nature.com/scientificreports OPEN Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease received: 15 June 2016 accepted: 04 January 2017 Published: 16 February 2017 M. M. Mariani1, T. Malm1,2, R. Lamb1, T. R. Jay1, L. Neilson1, ...
activity and that Fn14 can act independently from TWEAK in muscle, we suggest that manipulating Fn14 instead of TWEAK in theSOD1G93AALS mice could lead to differential and potentially improved benefits.#We thus investigated the contribution of Fn14 to disease phenotypes in theSOD1G93AALS mice....
(FDA) to treat the following neurologic pathologies: Alzheimer disease, amyotrophic lateral sclerosis, epilepsy, Huntington disease, migraine, multiple sclerosis, Parkinson disease, and pseudobulbar affect. A search of the literature was performed using the specific FDA-approved drug or drug classes in ...
Public health endorsements during the present COVID-19 pandemic has led the governments of largely affected countries to imply policies that restrict social mobility to slow COVID-19 spread. The study aimed to explore the effects of COVID-19 home quarant