$金斯瑞生物科技(01548)$效应T细胞(effectorT cell,Teff cell)是一种我们再熟悉不过的免疫细胞了,形象地来说,它们就像身体里的战士一般,能识别被抗原入侵的宿主细胞,并且通过释放免疫活性物质,如白细胞介素,干扰素等达到杀伤靶细胞的目的。在面对癌变细胞时,它也首当其冲,不断为身体消灭着一波又一波的异常增殖者。...
1) effector T cells 效应T细胞 例句>> 2) effector T cell 效应性T细胞 1. Objective To study the effect of rapamycin in inducing na ve murineeffector T cell(Teff) convert to regulatory T cell(Treg) in vitro. 目的研究雷帕霉素对诱导na ve小鼠效应性T细胞(Teff)体外转化为调节性T细胞(Treg)的影响...
effector T cellsJunBTregsTo maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is ...
Previous works developed antigen-specific T cells from Aβ1–42immunization of non-transgenic (non-Tg) mice. However, those cells were polarized for a short period prior to adoptive transfer with uncertain phenotypes [18,19]. Here, we developed stable Aβ-specific Teff clones that were maintain...
OBJECTIVE--To detect GM1 deficiency and determine its role in effector T cells (Teffs) from NOD mice in establishing resistance to regulatory T-cell (Treg) suppression. RESEARCH DESIGN AND METHODS--CD4+ and CD8+ Teffs were isolated from spleens of prediabetic NOD mice for comparison with sim...
The transcriptional regulator Blimp1 plays crucial roles in controlling terminal differentiation in several lineages. In T cells, Blimp1 is expressed in both effector (Teff) and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (B
GITR is expressed at high baseline levels on Tregs and upregulated on activated CD4+ and CD8+ effector T cells (Teff) (Nocentini, Ronchetti, Petrillo, & Riccardi, 2012; Schaer, Murphy, & Wolchok, 2012). Thus, engagement of GITR affects both Teff and Tregs. The assays described here ...
T cellsCellular proliferationFACSTregAnalysis of T regulatory cells (Treg) and T effector cells (Teff) in experimental autoimmune encephalomyelitis is complicated by the fact that both cell types express CD4 and CD25. We demonstrate that encephalitogenic T cells, following antigen recognition, up-...
Forkhead box P3 (FOXP3) is considered a specific marker for CD4+CD25+ regulatory T (Treg) cells, but increasing evidence suggests that human CD4+CD25− effector T (Teff) cells can transiently express FOXP3 upon activation. We demonstrate that the signal transducer and activator of transcription...
Microglia activation followed the oscillations of MOG-specific Teff cells in the secondary lymphoid organs, but they were activated before MOG-specific T-cell peaks in the CNS. Finally, we assessed the role of B-cell depletion induced by anti-CD20 therapy in the dynamics of T cells in an ...