1) Effector/memory T cells 效应/记忆T细胞2) effector memory T cell 效应记忆性T细胞 1. Based on the ability to express chemokine receptor CCR7 and the phosphatase CD45RA,T cells can be divided into na(l|¨)ve T cells,central memory T cells(T_(CM) cells),and effector memory T cells...
网络效应记忆性T细胞;效应记忆T细胞 网络释义
Watch this Scientific Journal Video about Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH at JoVE.com
Thus, effector memory T‑cells play an important role in tissue damage and disease progression in AAV. Sequentially administered or combined with B‑cell depleting therapy, T‑cell-directed therapies, especially those directed against effector memory CD4+ T‑cells, may further improve the outco...
Here, we investigated a non-IgE-mediated food-allergic enteropathy model of ovalbumin (OVA) 23-3 mice expressing OVA-specific T-cell-receptor transgenes. Mesenteric lymph nodes (MLNs) and their pathogenic CD4+T cells were important to enteropathy occurrence and exacerbation when the mice were ...
Effector memory CD8 T cells have the capacity to reside long-term at epithelial surfaces, where they allow for rapid containment of the invading pathogens at the local entry site and prevent systemic spreading and excessive immune responses. The accumulation of tissue-specific memory T cell subsets...
Unfortunately, donor T cells can attack nonmalignant host tissues and cause graft-versus-host disease (GVHD). We previously reported that donor CD4+ effector memory T cells (TEMs) do not cause GVHD but transfer functional T-cell memory. In the present work, we demonstrate in an MHC-...
Adoptively transferred NY-ESO-1-specific re-directed T cells protected mice against challenge with endogenously NY-ESO-1-positive myeloma cells in a xenograft model. In conclusion, re-directed effector-and central memory T cells specifically recognized NY-ESO-1(157-165)/HLA-A*02:01-positive ...
Here, using magnetic beads and fluorescence-activated cell sorting, we extensively phenotype the Tck effector cells and conclude that effector function resides within the CD4+CD45RO+, CCR7-, CD49dhigh population, and that these cells are derived from the effector memory CD4+ T cells in resting...
Effector-memory T cells are strategically placed to epithelial tissues to provide frontline immune protection against pathogens. Their detrimental effects, however, have been rarely examined because of difficulty in sampling these T cells in pathological settings. Our previous studies suggested persistence ...