T cellsThe lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign pathogens, and cancer immunosurveillance. Within this complex structure, intranodal migration is vital for CD8+T cell activation and differentiation. Combining tissue clearing and ...
Andreas P Russ6, Tullia Lindsten3, Jordan S Orange2, Ananda W Goldrath7,8, Rafi Ahmed4 & Steven L Reiner1 Two seemingly unrelated hallmarks of memory CD8+ T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. ...
CD38 Bright Effector Memory CD8+ T Cell Populations Predict Acute Graft Versus Host DiseaseChronic allograft rejectionInduced protein 8-like 2Novel biomarkerTumor necrosis factorTumor necrosis factor-ainduced protein 8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the relationship ...
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular...
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. MAIT cells are CD161hiIL-18R伪+ and either CD4CD8 (DN) or CD8伪尾int T cells. We now show that they display an effector-memory phenotype (CD45... M Dusseaux,E Martin,N Serriari,... - ...
However, elevated levels of Mcl-1 promoted the differentiation of short-lived effector cells (SLECs) at the expense of the memory precursor effector cells (MPECs) and skewed the development of effector memory CD8 T cells to the detriment of central memory CD8 T cells and their poly...
mTOR regulates memory CD8 T-cell differentiation Memory CD8 T cells are a critical component of protective immunity and inducing effective memory T cell responses is a major goal of vaccines against chron... K Araki,AP Turner,VO Shaffer,... - 《Nature》 被引量: 1645发表: 2009年 Functional ...
T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in...
The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8+ T cells. During influenza vir
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in nave cells. The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation nave CD8+ T cells become com... S. M. and Kaech,R Ahmed...